Periodic Reporting for period 1 - EARLYDETECT (Development of an accurate, early diagnostic tool for ovarian cancer)
Período documentado: 2021-01-01 hasta 2022-06-30
In this project, we have developed a high-throughput clinical assay for the specific identification of unique overall glycan structures associated with ovarian cancer in serum. The assay incorporates our glycan recognition technology in the high-throughput Luminex platform, which is globally used in clinical diagnostics. Imprinted (molecularly moulded) nanoparticles have been produced that can selectively bind glycans. This nanoparticle development is based on our patented technology (Patent No: WO2015/118294). As part of the project, a strategy has been also devised to functionalise the glycans associated with OC that reduces significantly the costs of the glycans used to create the imprinted nanoparticles. The assay has undergone a series of optimization steps and extensive analytical validation to ensure reproducible results and we have now well-defined standard operating procedures in place.
Through this project we have developed a novel assay that has the potential to radically change the diagnostic standard of care for OC, ultimately saving lives and reducing the health, social and economic burden imposed by OC. Further clinical validation will be sought in the future to strength the validity of the new assay and bring it to the market.