Project description
Optimising obesity treatment through sorting into relevant groups
Obesity is often perceived as a lack of self control rather than a disease. The EU-funded SOPHIA project aims to challenge this misconception by providing evidence for disease heterogeneity and create a shared value where all the stakeholders can do well by doing good. Researchers will identify predictors of risks of obesity complications as well as the subpopulations who are at risk of specific complications (e.g. type 2 diabetes, T2D, cardiovascular disease, CVD, cancers and osteoarthritis). The project will also identify predictors of response to different obesity treatments. The outcomes of this research will allow patients to receive higher quality information which in turn will empower them to make decisions together with their healthcare professionals in regards to their treatment.
Objective
SOPHIA will optimise the future treatment of obesity. The challenge is that clinicians, payers and patients view obesity as a failure of self-control, rather than a disease. We will change this perspective by defining subpopulations in terms of (a) the risks of complications linked to obesity, (b) response to various obesity treatments. The subpopulations will be characterised in terms of operational variables (phenotypic, genetic, behavioural, environmental, and omics). These predictive variables will facilitate diagnosis and underpin personalised and protocolised obesity care.
Patient priorities regarding risk and response will influence all aspects of our work. SOPHIA will create a federated database of premier EU cohorts to identify operational variables that are predictive of risk and treatment response in people with and without diabetes. We will validate the predictive value of these variables before creating clinically-useful algorithms to decide “when-to-treat” and “how-to-treat”. Biomarker variables will feed into innovative assays, tests and research targets. We will interpret and analyse our results, to identify shared value across all stakeholders (patients, clinicians, industry, payers).
SOPHIA will change attitudes and experience of obesity by (1) demonstrating the heterogeneity of the disease, (2) identifying people at risk of complications, (3) identifying the best treatment for each individual, (4) delivering a common vocabulary and shared understanding of obesity, (5) demonstrating shared value, which combines commercial opportunity with societal benefit.
Our ambition will only be realised if (a) payers agree to fund treatment, (b) industry generate effective treatments, (c) clinicians are prepared to prescribe treatments, and (d) patients are prepared to take treatments. The evidence base does not currently exist. SOPHIA will deliver this evidence and the shared value analysis to drive this revolution in obesity care.
Fields of science
Keywords
Programme(s)
Funding Scheme
RIA - Research and Innovation actionCoordinator
4 Dublin
Ireland
See on map
Participants (38)
DD1 4HN Dundee
See on map
22100 Lund
See on map
EX4 4QJ Exeter
See on map
3015 GD Rotterdam
See on map
6200 MD Maastricht
See on map
89081 Ulm
See on map
405 30 Goeteborg
See on map
T12 YN60 Cork
See on map
A96 E8H2 DUBLIN
See on map
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
01307 Dresden
See on map
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
20052 Washington Dc
See on map
1206 Geneve
See on map
3000 Leuven
See on map
1000 Bruxelles / Brussel
See on map
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
20123 Milano
See on map
Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
00133 Roma
See on map
00185 Roma
See on map
17190 Girona
See on map
Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
08007 Barcelona
See on map
Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
31080 Pamplona
See on map
72074 Tuebingen
See on map
85399 Hallbergmoos
See on map
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
59037 Lille
See on map
D02 N820 Dublin
See on map
2880 Bagsvaerd
See on map
55218 Ingelheim
See on map
10004 New York
See on map
02111 Boston
See on map
33614 Tampa Fl
See on map
1131 Tolochenaz
See on map
Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
3712BA Huis Ter Heide
See on map
RG21 4FA Basingstoke
See on map
CT13 9NJ Sandwich
See on map
68125 Tel Aviv
See on map
1011 Lausanne
See on map
15462 SHARQ
See on map
75012 Paris
See on map
BS8 1QU Bristol
See on map