Objective
Small GTP-binding proteins of the Rab family are versatile regulators of various aspects of cellular traffic, including biogenesis, transport and targeting of vesicles. They are believed to be central coordinators of the organization of membranes sub-domains, essential to define the identity of organelles.
The main goal of this project is the biochemical characterization of multi-molecular complexes of Rab11 (involved in endosomal membrane traffic) with partners that include myosin V and effectors of the Rab11 -FIP family as a step towards the elucidation of the molecular basis for the unique functions of Rab proteins. These functions involve networks of protein-protein interactions, and it is therefore critical to know which interactions are established, how they are regulated by the nucleotide status of the regulatory Rab proteins, and what the role of Rab partners with dual specificities in this process is. The project will focus in particular on one of these effectors, Rab11-FIP3/Arfophilin, which also interacts with Arf GTP-binding proteins, which are major regulators of vesicle biogenesis in intracellular traffic.
The novel cross-talk capacity of this protein may represent a point of convergence of Rab11 and Arf GTPases to regulate membrane traffic and integrate distinct signals in the late endosomal-recycling compartment. The interactions of Rab proteins with their effectors, notably cross-talk effectors, are still poorly understood at the biochemical and structural levels. The current project, aimed at dissecting the biochemical basis for cross talk between two small GTP-binding proteins involved in traffic should thus yield results of great and general interest. Based on the expertise of the host laboratory on both Rab and Arf proteins, it is also expected t o lead to subsequent structural studies. More generally, dysfunction of Rab small GTPases in human diseases makes them potential targets for therapeutic intervention.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- natural sciences biological sciences genetics nucleotides
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.