Activation of Src kinases through dimerization suggests novel therapeutic opportunities

Project Information

Src dimerization

Grant agreement ID: 882247

DOI

10.3030/882247

Project closed

EC signature date 3 April 2020

Start date 1 June 2020

End date 31 May 2023

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost

€ 182 721,60

EU contribution

€ 182 721,60

Coordinated by

MEDICAL UNIVERSITY SOFIA
Bulgaria

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (4)

Proteomic analysis of Src family kinase phosphorylation states in cancer cells suggests deregulation of the unique domain

Author(s): Ruiz-Saenz A, Zahedi F, Peterson E, Yoo A, Dreyer CA, Spassov DS, Oses-Prieto J, Burlingame A, Moasser MM
Published in: Mol Cancer Res, Issue 19(6), 2021, Page(s) 957-967, ISSN 1541-7786
Publisher: American Association for Cancer Research
DOI: 10.1158/1541-7786.mcr-20-0825

A reversible SRC-relayed COX2 inflammatory program drives resistance to BRAF and EGFR inhibition in BRAFV600E colorectal tumors

Author(s): Ruiz-Saenz A, Atreya CE, Wang C, Pan B, Dreyer CA, Brunen D, Prahallad A, Muñoz DP, Ramms DJ, Burghi V, Spassov DS, Fewings E, Hwang YC, Cowdrey C, Moelders C, Schwarzer C, Wolf DM, Hann B, VandenBerg SR, Shokat K, Moasser MM, Bernards R, Gutkind JS, van 't Veer LJ, Coppé JP. A
Published in: Nature Cancer, Issue 4(2), 2023, Page(s) 240–256, ISSN 2662-1347
Publisher: Nature publishing group
DOI: 10.1038/s43018-022-00508-5

A role of salt bridges in mediating drug potency: A lesson from the N-myristoyltransferase inhibitors

Author(s): Spassov DS, Atanasova M, Doytchinova I
Published in: Front Mol Biosci, Issue 9, 2023, Page(s) 1066029, ISSN 2296-889X
Publisher: Frontiers
DOI: 10.3389/fmolb.2022.1066029

Novel Hits for N-Myristoyltransferase Inhibition Discovered by Docking-Based Screening

Author(s): Spassov DS, Atanasova M, Doytchinova I.
Published in: Molecules, Issue 27(17), 2022, Page(s) 5478, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules27175478