Objective
Inflammation-induced airway remodelling is a major pathophysiological feature in chronic respiratory diseases such as asthma. Remodelling of airway smooth muscle (ASM) may contribute to the chronic deterioration of airway function in these airway diseases through increases in mass, allowing exaggerated bronchus obstruction. Classically, this increase in mass is thought to be mediated by peptide growth factors. However, neurotransmitters and allergic mediators are increasingly being recognized as important t o airway remodelling by amplifying the effects induced by growth factors (cross-talk). Recent studies indicate that caveolae membrane compartments and their membrane marker proteins, the caveolin(s), regulate receptor mediated signalling events and cross-talk between signalling pathways. Our project will investigate the role of caveolae and caveolins in controlling the mentioned synergistic effects on proliferation of ASM cells.
Research groups from the U of Groningen (EU) and the U of Manitoba (Canada) will be involved as hosts. Both universities have longstanding experience in respiratory pharmacology (U of Groningen) and physiology (U of Manitoba), respectively, which will have synergistic impact on the quality of the research. In addition, the applicant will receive advanced training during his outgoing period, aimed to improve his expertise, international contacts, technical skills and mentoring skills to the extent of becoming a prominent candidate for a future tenure track position at the U of Groninge nor another EU university. Transfer of this knowledge to the U of Groningen is important for the continuation and expansion of the described line of research within the EU, which is warranted since this specific research area is currently dominated by North-American institutes. Being a EU research institute, the U of Groningen will then be better equipped to cope with the increasing demand in insight in (patho) physiology of obstructive airway diseases.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine pneumology asthma
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs
- medical and health sciences health sciences infectious diseases RNA viruses coronaviruses
- medical and health sciences basic medicine physiology
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-6
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
OIF - Marie Curie actions-Outgoing International Fellowships
Coordinator
GRONINGEN
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.