Characterization of the role of netrin-1 in the regulation of the Epithelial-to-Mesenchymal Transition during tumor progression.

Project description

Dissecting cancer hallmarks for treatment

Epithelial-to-mesenchymal transition (EMT) is a process whereby epithelial cells are transformed into mesenchymal cells, gaining the ability to detach from the original tissue and migrate to other sites. Apart from normal development, EMT is active in cancer driving tumour cell dissociation and metastasis, in addition to endowing cancer cells with stem cell properties and drug resistance. The EU-funded NetriCan project will investigate how an extracellular protein, known for its role in cell migration during development, regulates EMT in cancer cells. The project's results will substantiate the therapeutic potential of a strategy aiming at targeting this protein and help develop novel promising therapeutic approaches for patients with advanced solid tumours.

Fields of science

• medical and health sciences › clinical medicine › oncology

Programme(s)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Topic(s)

• MSCA-IF-2019 - Individual Fellowships

Call for proposal

H2020-MSCA-IF-2019

See other projects for this call

Funding Scheme

MSCA-IF-EF-RI - RI – Reintegration panel

Coordinator

UNIVERSITE LYON 1 CLAUDE BERNARD

Net EU contribution

€ 196 707,84

Address

Boulevard Du 11 Novembre 1918 Num43
69622 Villeurbanne Cedex
France

Region

Auvergne-Rhône-Alpes › Rhône-Alpes › Rhône

Activity type

Higher or Secondary Education Establishments

Links

Other funding

€ 0,00