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Nuclear Regulators of Fungal Enzymes

Project description

Engineering production of fungal biofuel

European goals to increase the share of environment friendly, renewable sources in energy production and achieving independence from crude oil and hydrocarbons represent the most urgent goals in the present agenda. Recently, the conversion of plant biomass to biofuels, especially saprobic microorganisms like filamentous fungi of the genus Aspergillus, has emerged as a hopeful route to alternative green energy. Unfortunately, a glucose accumulation during enzymatic hydrolysis of plant biomass results in transcriptional repression of genes coding for fungal enzymes and secretion that must be overcome. The EU-funded NURoFE project proposes a fellowship to explore new proteins enabling regulation of hydrolytic enzymes and secondary metabolites production in filamentous fungus Aspergillus nidulans for biotechnological processes.

Objective

The dependence of mankind on petroleum- and oil-based fuels as the main energy source is widely recognised as being accompanied by several problems that impact the global economy and environmental health. In recent years, the conversion of plant biomass to biofuels, in a process called 1st- (1G) and 2nd-generation (2G) biofuel-production, has gained significant interest as an environmentally friendly and naturally abundant alternative, renewable energy source. The EU (European Union) legislation implements that by 2020, 20% of energy must be derived from renewable sources, showing the importance that renewable energy source production will play in the future. Saprobic microorganisms, such as filamentous fungi of the genus Aspergillus, are of particular interest for this process as they secrete a vast array of plant biomass hydrolyzing enzymes. A major drawback in the production of renewable biofuels is built-up of glucose during enzymatic hydrolysis of plant biomass, resulting in the transcriptional repression of fungal enzyme-encoding genes and subsequent secretion. The here described fellowship is proposing to uncover novel proteins involved in the regulation of hydrolytic enzymes and secondary metabolites production in the filamentous fungus Aspergillus nidulans that can be explored for biotechnological processes. To implement this project, the candidate will be hosted at the National University of Ireland in Maynooth in the laboratory of Fungal Genetics and Secondary Metabolism, under the supervision of Dr. Ozgur Bayram.

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Programme(s)

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Topic(s)

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Funding Scheme

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MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)

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Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

(opens in new window) H2020-MSCA-IF-2019

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Coordinator

NATIONAL UNIVERSITY OF IRELAND MAYNOOTH
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 196 590,72
Address
CO KILDARE
W23 Maynooth
Ireland

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Region
Ireland Eastern and Midland Mid-East
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 196 590,72
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