Project description
Finding a new pathway for a comprehensive structural analysis of biological systems
For scientists to be able to understand and control biological processes, they need precise structural, conformational and chemical information on biological molecules. Different methods for the structural characterisation of folded proteins and protein complexes include cryo-electron microscopy (cryo-EM), native mass spectrometry (native MS) and preparative mass spectrometry (prep-MS). The EU-funded PNMS project intends to establish a new versatile pathway for a comprehensive structural analysis of biological systems by combining native MS, prep-MS and cryo-EM. This approach, called preparative native mass spectrometry, will involve designing ion optics to couple a mass-selected molecular ion beam from a commercial high-performance MS and a landing stage to add deposition capability. The project will enable a better understanding of structural variety, protein interactions and synthetic structures.
Fields of science
Programme(s)
Funding Scheme
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
Coordinator
OX1 2JD Oxford
United Kingdom
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