Project description
3D printing of biomaterials with antibacterial properties
The global issue of antimicrobial drug resistance necessitates novel interventions. Biomaterials with antimicrobial properties are emerging as an attractive solution for a wide variety of applications including wound healing and tissue engineering, where persistent bacteria pose a serious health threat. The EU-funded GelPrint project is developing peptide-based antimicrobial or bacteriostatic hydrogels that can be 3D printed. Researchers are exploring lysine-based polypeptides and investigating their antibacterial properties and feasibility to be used in tissue regeneration. The GelPrint printable tissue regenerating platform is highly innovative and has great clinical potential to address nosocomial infections.
Objective
Biomaterials with antimicrobial properties which can be used for wound healing and tissue engineering applications offer high application potential due to the global increase of antimicrobial resistance. While polypeptides own this potential, their integration into a materials platform has not been realised to date. The overall objective of this project is to develop 3D printable antimicrobial or bacteriostatic polypeptide hydrogel materials, which can be employed in tissue regeneration applications to prevent bacterial growth. In particular, the goals include synthesis of sets of cross-linked polypeptide hydrogels based on lysine (Lys) and investigation of their hydrogel properties and 3D printability. Moreover, evaluation, validation and quantification of the antimicrobial properties of the hydrogels as well as the proof of concept demonstration for their feasibility in tissue regeneration will be addressed. The synthesis of these particular copolypeptides hydrogels is highly novel and their exploitation as a printable tissue regenerating platform is timely, of high fundamental as well as clinical impact and considered a new approach. The proposed project is broadly interdisciplinary, as disciplines of polymer chemistry, biomaterials science and engineering, microbiology and in vitro assessment techniques will be combined. The high-level science combined with complementary training will significantly advance the career opportunities of the applicant. Moreover, the excellent match of the applicant`s expertise with the project and the host organisation will ensure a strong transfer of knowledge between all participants. The potential of the proposed project is further highlighted by the possible commercial exploitation of the scientific findings and developments. Finally, it will enable new collaboration opportunities between research groups from different scientific fields.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences medical biotechnology tissue engineering
- natural sciences chemical sciences polymer sciences
- engineering and technology industrial biotechnology biomaterials
- natural sciences biological sciences microbiology
- medical and health sciences basic medicine pharmacology and pharmacy drug resistance antibiotic resistance
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2019
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
2 DUBLIN
Ireland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.