Descrizione del progetto
Stampa 3D di biomateriali con proprietà antibatteriche
Il problema globale della resistenza ai farmaci antimicrobici necessita di nuovi interventi. I biomateriali con proprietà antimicrobiche stanno emergendo come una soluzione allettante per un’ampia varietà di applicazioni, tra cui guarigione delle ferite e ingegneria tissutale, dove i batteri persistenti rappresentano una seria minaccia per la salute. Il progetto GelPrint, finanziato dall’UE, sta sviluppando idrogel antimicrobici o batteriostatici basati su peptidi che possono essere stampati. I ricercatori stanno esplorando i polipeptidi basati sulla lisina, nonché studiando le loro proprietà antibatteriche e la fattibilità per l’utilizzo nella rigenerazione tissutale. La piattaforma di rigenerazione tissutale stampabile di GelPrint è estremamente innovativa e possiede un enorme potenziale clinico per affrontare le infezioni nosocomiali.
Obiettivo
Biomaterials with antimicrobial properties which can be used for wound healing and tissue engineering applications offer high application potential due to the global increase of antimicrobial resistance. While polypeptides own this potential, their integration into a materials platform has not been realised to date. The overall objective of this project is to develop 3D printable antimicrobial or bacteriostatic polypeptide hydrogel materials, which can be employed in tissue regeneration applications to prevent bacterial growth. In particular, the goals include synthesis of sets of cross-linked polypeptide hydrogels based on lysine (Lys) and investigation of their hydrogel properties and 3D printability. Moreover, evaluation, validation and quantification of the antimicrobial properties of the hydrogels as well as the proof of concept demonstration for their feasibility in tissue regeneration will be addressed. The synthesis of these particular copolypeptides hydrogels is highly novel and their exploitation as a printable tissue regenerating platform is timely, of high fundamental as well as clinical impact and considered a new approach. The proposed project is broadly interdisciplinary, as disciplines of polymer chemistry, biomaterials science and engineering, microbiology and in vitro assessment techniques will be combined. The high-level science combined with complementary training will significantly advance the career opportunities of the applicant. Moreover, the excellent match of the applicant`s expertise with the project and the host organisation will ensure a strong transfer of knowledge between all participants. The potential of the proposed project is further highlighted by the possible commercial exploitation of the scientific findings and developments. Finally, it will enable new collaboration opportunities between research groups from different scientific fields.
Campo scientifico
- medical and health sciencesmedical biotechnologytissue engineering
- natural scienceschemical sciencespolymer sciences
- engineering and technologyindustrial biotechnologybiomaterials
- natural sciencesbiological sciencesmicrobiology
- medical and health sciencesbasic medicinepharmacology and pharmacydrug resistanceantibiotic resistance
Programma(i)
Argomento(i)
Meccanismo di finanziamento
MSCA-IF-EF-ST - Standard EFCoordinatore
2 Dublin
Irlanda