Inhibiting BAF to Improve Gene Delivery

Project Information

IBAF

Grant agreement ID: 884505

DOI 10.3030/884505

EC signature date 30 April 2020

Start date 1 November 2020

End date 31 October 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 390 625,00

EU contribution € 2 390 625,00

Coordinated by

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (9)

The intracellular visualization of exogenous DNA in fluorescence microscopy

Author(s): Christina Greitens, Jean-Christophe Leroux, Michael Burger
Published in: Drug Delivery and Translational Research, Issue 14, 2024, Page(s) 2242-2261, ISSN 2190-393X
Publisher: Springer Pub. Co.,
DOI: 10.1007/s13346-024-01563-4

Modular Calcium‐Responsive and CD9‐Targeted Phospholipase System Enhancing Endosomal Escape for DNA Delivery

Author(s): Alexander Klipp, Christina Greitens, David Scherer, Alexander Elsener, Jean‐Christophe Leroux, Michael Burger
Published in: Advanced Science, Issue 12, 2025, ISSN 2198-3844
Publisher: Wiley
DOI: 10.1002/advs.202410815

Activity-Based Approach for Selective Molecular CO 2 Sensing

Author(s): Ori Green; Patrick Finkelstein; Miguel A. Rivero-Crespo; Marius D. R. Lutz; Michael K. Bogdos; Michael Burger; Jean-Christophe Leroux; Bill Morandi
Published in: Journal of the American Chemical Society, 144 (19), Issue 3, 2022, Page(s) 8717-8724, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.2c02361

Hurdles to healing: Overcoming cellular barriers for viral and nonviral gene therapy

Author(s): Steffen Honrath, Michael Burger, Jean-Christophe Leroux
Published in: International Journal of Pharmaceutics, Issue 674, 2025, Page(s) 125470, ISSN 0378-5173
Publisher: Elsevier BV
DOI: 10.1016/j.ijpharm.2025.125470

The TFAMoplex-Conversion of the Mitochondrial Transcription Factor A into a DNA Transfection Agent

Author(s): Burger, Michael; Kaelin, Seraina; Leroux, Jean-Christophe; id_orcid0000-0001-5601-1292
Published in: Advanced Science, 9 (8), Issue 2104987, 2022, ISSN 2198-3844
Publisher: Wiley-VCH
DOI: 10.1002/advs.202104987

Enzymatic absorption promoters for non-invasive peptide delivery

Author(s): Marilena Bohley Steiger, Angela Steinauer, Daniel Gao, David Klein Cerrejon, Hanna Krupke, Miguel Heussi, Padryk Merkl, Alexander Klipp, Michael Burger, Cristina Martin-Olmos, Jean-Christophe Leroux
Published in: Journal of Controlled Release, Issue 382, 2025, Page(s) 113675, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2025.113675

Get out or die trying: peptide- and protein-based endosomal escape of RNA therapeutics

Author(s): Klipp, Alexander; Burger, Michael; Leroux, Jean-Christophe
Published in: Advanced Drug Delivery Reviews, 200, Issue 3, 2023, Page(s) 115047, ISSN 1872-8294
Publisher: Elsevier
DOI: 10.3929/ethz-b-000624998

Revival of Bioengineered Proteins as Carriers for Nucleic Acids

Author(s): David Scherer, Michael Burger, Jean-Christophe Leroux
Published in: Bioconjugate Chemistry, Issue 35, 2024, Page(s) 561-566, ISSN 1043-1802
Publisher: American Chemical Society
DOI: 10.1021/acs.bioconjchem.4c00079

Closing the gap: Nonviral TFAMoplex transfection boosted by bZIP domains compared to AAV-mediated transduction

Author(s): Steffen Honrath, Miguel Heussi, Lukas Beckert, David Scherer, Roderick Y.H. Lim, Michael Burger, Jean-Christophe Leroux
Published in: Molecular Therapy Nucleic Acids, Issue 36, 2025, Page(s) 102526, ISSN 2162-2531
Publisher: Nature Publishing Group
DOI: 10.1016/j.omtn.2025.102526

Non-peer reviewed articles (1)

Interaction proteomics analysis to provide insight into TFAMoplex-mediated transfection

Author(s): Steffen Honrath, David Scherer, Michael Burger, Jean-Christophe Leroux
Published in: Journal of Controlled Release, Issue 373, 2024, Page(s) 252-264, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2024.07.025