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Inhibiting BAF to Improve Gene Delivery

Project description

A novel way to improve gene delivery

Gene therapy and gene editing necessitate the delivery of nucleic acids into cells. However, there are various cellular bottlenecks that hamper the effectiveness of delivery. These include endosomal sequestration, poor nuclear translocation and, most importantly, retention of introduced nucleic acids in membrane cages following recognition by the barrier-to-autointegration factor (BAF) protein. Scientists of the EU-funded IBAF project will address this issue and increase the cytosolic availability and mobility of transfected DNA through the transient suppression of the BAF. The project's findings will advance our understanding of this unexplored DNA retention mechanism, and provide transfection enhancers that can boost already-existing gene delivery platforms.

Call for proposal

ERC-2019-ADG
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Host institution

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Address
Raemistrasse 101
8092 Zuerich
Switzerland
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 2 390 625

Beneficiaries (1)

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland
EU contribution
€ 2 390 625
Address
Raemistrasse 101
8092 Zuerich
Activity type
Higher or Secondary Education Establishments