Project description
A novel way to improve gene delivery
Gene therapy and gene editing necessitate the delivery of nucleic acids into cells. However, there are various cellular bottlenecks that hamper the effectiveness of delivery. These include endosomal sequestration, poor nuclear translocation and, most importantly, retention of introduced nucleic acids in membrane cages following recognition by the barrier-to-autointegration factor (BAF) protein. Scientists of the EU-funded IBAF project will address this issue and increase the cytosolic availability and mobility of transfected DNA through the transient suppression of the BAF. The project's findings will advance our understanding of this unexplored DNA retention mechanism, and provide transfection enhancers that can boost already-existing gene delivery platforms.
Fields of science
- natural sciencesbiological sciencesbiochemistrybiomoleculesnucleic acids
- medical and health sciencesmedical biotechnologygenetic engineeringgene therapy
- natural sciencesbiological sciencesgeneticsDNA
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteins
- engineering and technologynanotechnologynano-materials
Programme(s)
Topic(s)
Funding Scheme
ERC-ADG - Advanced GrantHost institution
8092 Zuerich
Switzerland
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Beneficiaries (1)
8092 Zuerich
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