MECHANISMS BEHIND RESIDUAL DISEASE IN COLORECTAL CANCER and MODELLING OF THERAPIES THAT PREVENT RELAPSE

Project Information

residualCRC

Grant agreement ID: 884623

DOI

10.3030/884623

Project closed

EC signature date 22 July 2020

Start date 1 September 2020

End date 31 August 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 500 000,00

EU contribution

€ 2 500 000,00

Coordinated by

FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA)
Spain

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (8)

Mex3a marks drug-tolerant persister colorectal cancer cells that mediate relapse after chemotherapy

Author(s): Adrián Álvarez-Varela, Laura Novellasdemunt, Francisco M. Barriga, Xavier Hernando-Momblona, Adrià Cañellas-Socias, Sara Cano-Crespo, Marta Sevillano, Carme Cortina, Diana Stork, Clara Morral, Gemma Turon, Felipe Slebe, Laura Jiménez-Gracia, Ginevra Caratù, Peter Jung, Giorgio Stassi, Holger Heyn, Daniele V. F. Tauriello, Lidia Mateo, Sabine Tejpar, Elena Sancho, Camille Stephan-Otto Attolin
Published in: Nature Cancer, Issue 3, 2022, Page(s) 1052-1070, ISSN 2662-1347
Publisher: Nature Portfolio
DOI: 10.1038/s43018-022-00402-0

Metastatic recurrence in colorectal cancer arises from residual EMP1+ cells

Author(s): Adrià Cañellas-Socias, Carme Cortina, Xavier Hernando-Momblona, Sergio Palomo-Ponce, Eoghan J. Mulholland, Gemma Turon, Lidia Mateo, Sefora Conti, Olga Roman, Marta Sevillano, Felipe Slebe, Diana Stork, Adrià Caballé-Mestres, Antonio Berenguer-Llergo, Adrián Álvarez-Varela, Nicola Fenderico, Laura Novellasdemunt, Laura Jiménez-Gracia, Tamara Sipka, Lidia Bardia, Patricia Lorden, Julien Colo
Published in: Nature, Issue 611, 2022, Page(s) 603-613, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-05402-9

Cancer drug-tolerant persister cells: from biological questions to clinical opportunities

Author(s): Mariangela Russo, Mengnuo Chen, Elisa Mariella, Haoning Peng, Sumaiyah K. Rehman, Elena Sancho, Alberto Sogari, Tzen S. Toh, Nathalie Q. Balaban, Eduard Batlle, Rene Bernards, Mathew J. Garnett, Matthew Hangauer, Eleonora Leucci, Jean-Christophe Marine, Catherine A. O’Brien, Yaara Oren, E. Elizabeth Patton, Caroline Robert, Susan M. Rosenberg, Shensi Shen, Alberto Bardelli
Published in: Nature Reviews Cancer, Issue 24, 2024, Page(s) 694-717, ISSN 1474-175X
Publisher: Nature Publishing Group
DOI: 10.1038/s41568-024-00737-z

A plastic EMP1⁺ to LGR5⁺ cell state conversion as a bypass to KRAS-G12D pharmacological inhibition in metastatic colorectal cancer

Author(s): Alessia Centonze, Adrià-Jaume Roura, Meritxell Novillo-Font, Cristina Giordano, Xavier Hernando-Momblona, Montserrat Llanses, Paula Prats, Marta Sevillano, Débora Cabot, Mireia Novell, Gabriel Pabst, Florian Andersch, Adrià Cañellas-Socias, Chong Zhang, Nikolaos-Nikiforos Giakoumakis, Hugh Sparks, Chris Dunsby, Julien Colombelli, Asunción Fernández-Barral, Elena Sancho, Camille Stephan-Otto
Published in: Cancer Discovery, 2025, ISSN 2159-8274
Publisher: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-25-0679

Five latent factors underlie response to immunotherapy

Author(s): Joseph Usset, Axel Rosendahl Huber, Maria A. Andrianova, Eduard Batlle, Joan Carles, Edwin Cuppen, Elena Elez, Enriqueta Felip, Marina Gómez-Rey, Deborah Lo Giacco, Francisco Martinez-Jimenez, Eva Muñoz-Couselo, Lillian L. Siu, Josep Tabernero, Ana Vivancos, Ferran Muiños, Abel Gonzalez-Perez, Nuria Lopez-Bigas
Published in: Nature Genetics, Issue 56, 2024, Page(s) 2112-2120, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-024-01899-0

Overcoming TGFβ-mediated immune evasion in cancer

Author(s): Daniele V.F. Tauriello, Elena Sancho, Eduard Batlle
Published in: Nature Reviews Cancer, Issue Jan;22(1), 2022, Page(s) 25-44, ISSN 1474-1768
Publisher: Nature Publishing Group
DOI: 10.1038/s41568-021-00413-6

Mechanisms of metastatic colorectal cancer

Author(s): Adrià Cañellas-Socias, Elena Sancho, Eduard Batlle
Published in: Nature Reviews Gastroenterology & Hepatology, Issue 21, 2024, Page(s) 609-625, ISSN 1759-5045
Publisher: Nature Publishing Group
DOI: 10.1038/s41575-024-00934-z

Membrane to cortex attachment determines different mechanical phenotypes in LGR5+ and LGR5- colorectal cancer cells

Author(s): Sefora Conti, Valeria Venturini, Adrià Cañellas-Socias, Carme Cortina, Juan F. Abenza, Camille Stephan-Otto Attolini, Emily Middendorp Guerra, Catherine K. Xu, Jia Hui Li, Leone Rossetti, Giorgio Stassi, Pere Roca-Cusachs, Alba Diz-Muñoz, Verena Ruprecht, Jochen Guck, Eduard Batlle, Anna Labernadie, Xavier Trepat
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-47227-2