Designer enzymes featuring unnatural amino acids as catalytic residue

Project Information

DENZUAC

Grant agreement ID: 885396

DOI 10.3030/885396

EC signature date 21 April 2020

Start date 1 September 2020

End date 31 August 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 499 996,00

EU contribution € 2 499 996,00

Coordinated by

RIJKSUNIVERSITEIT GRONINGEN
Netherlands

Publications

Peer reviewed articles (7)

Unlocking Iminium Catalysis in Artificial Enzymes to Create a Friedel-Crafts Alkylase

Author(s): Reuben B. Leveson-Gower; Zhi Zhou; Ivana Drienovská; Gerard Roelfes
Published in: ACS Catalysis, Issue 3, 2021, Page(s) 6763–6770, ISSN 2155-5435
Publisher: American Chemical Society
DOI: 10.1021/acscatal.1c00996

Chemogenetic Tags with Probe Exchange for Live-Cell Fluorescence Microscopy.

Author(s): Aditya Iyer; Maxim Baranov; Alexander J. Foster; Shreyans Chordia; Gerard Roelfes; Rifka Vlijm; Geert van den Bogaart; Bert Poolman
Published in: Acs Chemical Biology, 16, 891 - 904, Issue 5, 2021, Page(s) 891–904, ISSN 1554-8929
Publisher: American Chemical Society
DOI: 10.1021/acschembio.1c00100

Biocatalytic Friedel-Crafts Reactions

Author(s): Reuben B. Leveson‐Gower; Gerard Roelfes
Published in: ChemCatChem, Issue 1, 2022, Page(s) e202200636, ISSN 1867-3899
Publisher: Wiley-VCH GmbH
DOI: 10.1002/cctc.202200636

Tandem Friedel-Crafts-Alkylation-Enantioselective-Protonation by Artificial Enzyme Iminium Catalysis

Author(s): Reuben B. Leveson-Gower; Ruben de Boer; Gerard Roelfes
Published in: ChemCatChem, Issue 1, 2022, Page(s) e202101875, ISSN 1867-3899
Publisher: Wiley-VCH GmbH
DOI: 10.1002/cctc.202101875

Repurposed and artificial heme enzymes for cyclopropanation reactions.

Author(s): Gerard Roelfes
Published in: Journal of Inorganic Biochemistry, 222:111523. ELSEVIER SCIENCE INC, Issue 4, 2021, Page(s) 111523, ISSN 0162-0134
Publisher: Elsevier BV
DOI: 10.1016/j.jinorgbio.2021.111523

Synergistic Catalysis of Tandem Michael Addition/Enantioselective Protonation Reactions by an Artificial Enzyme.

Author(s): Zhi Zhou; Gerard Roelfes
Published in: ACS Catalysis, Issue 3, 2021, Page(s) 366–9369, ISSN 2155-5435
Publisher: American Chemical Society
DOI: 10.1021/acscatal.1c02298

An In Vivo Biocatalytic Cascade Featuring an Artificial Enzyme Catalyzed New-to-Nature Reaction

Author(s): Linda Ofori Atta; Zhi Zhou; Gerard Roelfes
Published in: Angewandte Chemie International Edition, Issue 2, 2023, Page(s) e202214191, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202214191