Advancing whole heart simulators
It is well established that muscle contraction involves the cyclical interaction of myosin motors with actin filaments that lead to a sliding movement. The recently delineated mechanosensing (MS) mechanism active in the myosin thick filament addresses unresolved mechanistic gaps related to the fine regulation of muscle contraction. The scope of the EU-funded Heart Fi-Re project is to develop a mathematical model capable of quantitatively characterising the MS mechanism at the fibre level. The rationale is to incorporate this mechanosensing model into a powerful whole heart simulator and assess the macroscopic impact of the MS mechanism in various cardiomyopathies.
Field of science
- /natural sciences/mathematics/applied mathematics/mathematical model
Call for proposal
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