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HEART FIne REgulation through mechanosensing in myosin filaments: merging theory and experiments into a multi-scale heart simulator

Project description

Advancing whole heart simulators

It is well established that muscle contraction involves the cyclical interaction of myosin motors with actin filaments that lead to a sliding movement. The recently delineated mechanosensing (MS) mechanism active in the myosin thick filament addresses unresolved mechanistic gaps related to the fine regulation of muscle contraction. The scope of the EU-funded Heart Fi-Re project is to develop a mathematical model capable of quantitatively characterising the MS mechanism at the fibre level. The rationale is to incorporate this mechanosensing model into a powerful whole heart simulator and assess the macroscopic impact of the MS mechanism in various cardiomyopathies.

Field of science

  • /natural sciences/mathematics/applied mathematics/mathematical model

Call for proposal

H2020-MSCA-IF-2019
See other projects for this call

Funding Scheme

MSCA-IF-GF - Global Fellowships

Coordinator

UNIVERSITA DEGLI STUDI DI PADOVA
Address
Via 8 Febbraio 2
35122 Padova
Italy
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 276 498,24

Partners (1)

RIKEN THE INSTITUTE OF PHYSICAL ANDCHEMICAL RESEARCH
Japan
Address
Hirosawa 2-1
351 0198 Wako Shi Saitama
Activity type
Research Organisations