HEART FIne REgulation through mechanosensing in myosin filaments: merging theory and experiments into a multi-scale heart simulator

Project Information

Heart Fi-Re

Grant agreement ID: 886232

DOI 10.3030/886232

EC signature date 17 March 2020

Start date 1 July 2021

End date 29 September 2024

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 276 498,24

EU contribution € 276 498,24

Coordinated by

UNIVERSITA DEGLI STUDI DI PADOVA
Italy

Publications

Peer reviewed articles (4)

Cytosolic Ca2+ gradients and mitochondrial Ca2+ uptake in resting muscle fibers: A model analysis

Author(s): Marcucci Lorenzo, Michelucci Antonio, Reggiani Carlo
Published in: Biophysical Reports, 2023, ISSN 2667-0747
Publisher: Biophysical Society
DOI: 10.1016/j.bpr.2023.100117

A controversial issue: Can mitochondria modulate cytosolic calcium and contraction of skeletal muscle fibers?

Author(s): Reggiani, Carlo; Marcucci, Lorenzo
Published in: THE JOURNAL OF GENERAL PHYSIOLOGY, 2022, ISSN 0022-1295
Publisher: Rockefeller University Press
DOI: 10.1085/jgp.202213167

Activation of skeletal muscle is controlled by a dual-filament mechano-sensing mechanism

Author(s): Elisabetta Brunello, Lorenzo Marcucci, Malcolm Irving, Luca Fusi
Published in: Proceedings of the National Academy of Sciences of the United States of America, 2023, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2302837120

Muscle Mechanics and Thick Filament Activation: An Emerging Two-Way Interaction for the Vertebrate Striated Muscle Fine Regulation

Author(s): Lorenzo Marcucci
Published in: International Journal of Molecular Sciences, 2023, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24076265