Chromatin Regulation Of Normal And Malignant Haematopoiesis

Project description

Chromatin regulation in haematopoiesis

Chromatin factors (CFs) drive cellular fate and developmental lineage decision by participating in dynamic chromatin complexes and regulating gene expression. Given that CFs are among the most frequently mutated proteins in various blood malignancies, as for example in mixed lineage leukemia (MLL), the EU-funded ChRONAM-H project set out to determine the role of these proteins in haematopoietic lineage commitment. Through state-of-the-art chromatin profiling technologies, scientists will link CFs with transcription factors in both normal and malignant haematopoiesis. Results will provide fundamental information on genome regulatory mechanisms and also identify molecular targets to fight leukemia.

Fields of science

• medical and health sciences › clinical medicine › oncology › leukemia
• natural sciences › biological sciences › genetics › genomes
• natural sciences › biological sciences › biochemistry › biomolecules › proteins › enzymes
• natural sciences › biological sciences › genetics › epigenetics

Programme(s)

• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Topic(s)

• MSCA-IF-2019 - Individual Fellowships

Call for proposal

H2020-MSCA-IF-2019
See other projects for this call

Funding Scheme

MSCA-IF-EF-ST - Standard EF

Coordinator

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

Address

Trinity Lane The Old Schools
CB2 1TN Cambridge
United Kingdom

Activity type

Higher or Secondary Education Establishments

Links

EU contribution

€ 212 933,76