Project description
Chromatin regulation in haematopoiesis
Chromatin factors (CFs) drive cellular fate and developmental lineage decision by participating in dynamic chromatin complexes and regulating gene expression. Given that CFs are among the most frequently mutated proteins in various blood malignancies, as for example in mixed lineage leukemia (MLL), the EU-funded ChRONAM-H project set out to determine the role of these proteins in haematopoietic lineage commitment. Through state-of-the-art chromatin profiling technologies, scientists will link CFs with transcription factors in both normal and malignant haematopoiesis. Results will provide fundamental information on genome regulatory mechanisms and also identify molecular targets to fight leukemia.
Fields of science
Programme(s)
Call for proposal
H2020-MSCA-IF-2019
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Funding Scheme
MSCA-IF-EF-ST - Standard EFCoordinator
CB2 1TN Cambridge
United Kingdom
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