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Chromatin Regulation Of Normal And Malignant Haematopoiesis

Project description

Chromatin regulation in haematopoiesis

Chromatin factors (CFs) drive cellular fate and developmental lineage decision by participating in dynamic chromatin complexes and regulating gene expression. Given that CFs are among the most frequently mutated proteins in various blood malignancies, as for example in mixed lineage leukemia (MLL), the EU-funded ChRONAM-H project set out to determine the role of these proteins in haematopoietic lineage commitment. Through state-of-the-art chromatin profiling technologies, scientists will link CFs with transcription factors in both normal and malignant haematopoiesis. Results will provide fundamental information on genome regulatory mechanisms and also identify molecular targets to fight leukemia.

Call for proposal

H2020-MSCA-IF-2019
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Coordinator

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
United Kingdom

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Activity type
Higher or Secondary Education Establishments
EU contribution
€ 212 933,76