Periodic Reporting for period 2 - NANOMET (Development and standardisation of methods for the safety testing of manufactured nanomaterials at OECD.)
Période du rapport: 2021-11-01 au 2023-10-31
The NANOMET project has the overall objective of publishing globally adopted standards, harmonised methodologies and reports for the safety testing of manufactured nanomaterials. Different work packages address different testing areas: physical-chemical properties, effects on biotic systems, environmental fate and behaviour and human health effects. Digital communication and dissemination activities are foreseen in the course of the project to promote OECD adopted methods, guidance material and reports containing public data.
In the first eighteen months of the NANOMET project, three OECD Guidance Documents were published to address the safety testing of nanomaterials in aquatic toxicity studies and in environmental fate and behaviour studies. Guidance material is also under review for the testing and evaluating the genotoxic potential of nanomaterials. Several projects to develop harmonised test methods for the nanospecific physical-chemical properties have started and three draft Test Guidelines are under review so far. Virtual meetings for specific projects have been organised, as well as public bilingual webinars to promote the publication of the Guidance Documents.
In the second period (from November 2021 to the end of October 2023), three new Test Guidelines (TG 124, TG 125, TG 126) were published with associated validation reports, two study reports on the applicability of in vitro Test Guidelines on skin sensitisation and on genotoxicity *TG 442D and TG 487) were published, and four new draft Test Guidelines or Guidance Documents were developed for review by OECD experts. Several joint events with sister projects were organised at the OECD, one webinar for the promotion of a new Test Guideline was organised with a replay available, several newsletter mentioning progress with the NANOMET project were published every 9 months and a brochure regrouping all activities and deliverables of the NANOMET project was published.
In the second period (from November 2021 to the end of October 2023), three new Test Guidelines (TG 124, TG 125, TG 126) were published with associated validation reports, two study reports on the applicability of in vitro Test Guidelines on skin sensitisation and on genotoxicity *TG 442D and TG 487) were published, and four new draft Test Guidelines or Guidance Documents were developed for review by OECD experts. Several joint events with sister projects were organised at the OECD, one webinar for the promotion of a new Test Guideline was organised with a replay available, several newsletter mentioning progress with the NANOMET project were published every 9 months and a brochure regrouping all activities and deliverables of the NANOMET project was published.
Once the project is completed, several harmonised OECD Test Guidelines and Guidance Documents for the safety testing of nanomaterials will be published, especially in the critical area of physical-chemical properties, which determines important characteristics that other chemicals do not present. Large networks of experts will have been established at the global level, and regulators will be better informed to address any specific. Several webinars will have been held and made available on the OECD ENV/EHS Youtube channel as an on-line resource presenting the state-of-the-art on nanomaterials safety testing.