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The Conformation Of S-phase chroMOSomes

Project description

Delineating chromosomal architecture during mitosis

Eukaryotic cells temporally regulate DNA replication at multiple origins throughout chromosomes. Failure to do so results in genomic stress and may lead to cancer. The scope of the EU-funded COSMOS project is to understand the mechanism behind this temporal regulation and delineate the propagation of the structural elements at the chromosomal origins of replication during mitosis. To achieve this, researchers will employ Hi-C, a method for studying the three-dimensional architecture of genomes, to generate information separately for each sister chromatid. Insight into the interplay between replication timing, DNA damage and chromosome structure will help scientists comprehend the causes of chromosomal aberrations with obvious consequences for cancer therapy.

Coordinator

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Net EU contribution
€ 271 732,80
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
United Kingdom

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Region
East of England East Anglia Cambridgeshire CC
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Partners (1)

Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

UNIVERSITY OF MASSACHUSETTS
United States
Net EU contribution
€ 0,00
Address
Butterfield Terrace 70
01003 Amherst

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Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 165 265,92