Project description
Gut microbiota and immune system crosstalk in obesity
High calorie intake combined with a sedentary lifestyle have led to obesity reaching epidemic proportions. Accumulating evidence underscores the effect of nutrition on gut microbiota composition, which in turn impacts metabolic health beyond the intestine. The aim of the EU-funded MicroILCs project is to identify the key determinants of the gut ecosystem for the immune responses of the innate lymphoid cells (ILCs) in particular. Identification of intestinal human bacteria with immune regulatory properties will provide insight into how microbiota control immune responses to high-energy diets. Scientists hope to translate the knowledge generated into microbiota-modulating strategies that can be applied in the clinical setting to tackle metabolic disorders.
Objective
Obesity reaches epidemic proportions and currently represents a significant public health challenge. Curbing the prevalence of obesity is one health policy priority, whose achievement requires more effective preventive measures. A high-caloric diet and sedentary lifestyle are key determinants of obesity. The diet shapes gut microbiota composition, which may partly explain why microbiota alterations are associated with an obese phenotype in humans. These microbial alternations have been proven to contribute to energy metabolism and fat storage. This evidence has represented an unprecedented shift in the way we envision obesity management. However, translating this knowledge into microbiota modulation strategies that can be applied in the clinical setting needs a better understanding of the active players within the gut ecosystem, as well as, of the mechanisms underlying their dialog with the host. Preclinical studies show that the microbiota shapes immune responses beyond the intestine with consequences for metabolic health. This proposal aims to decipher the regulatory role of indigenous intestinal bacteria on the recently discovered innate lymphoid cells (ILCs). To achieve this goal, we will use the collection of intestinal human bacteria created in the context of the EUproject MyNewGut by the host institution, first, to identify those with ILCs stimulatory properties and second, to perform mechanistic studies in wild-type and mutant murine models of diet-induced obesity coupled to in vitro experiments with primary cell cultures. Overall, the objective of the MicroILCs proposal is to move forward in the understanding of the mechanisms whereby the gut microbiota controls the immune response to high-energy diets and affects the metabolic phenotype.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences public health
- natural sciences biological sciences microbiology bacteriology
- medical and health sciences basic medicine immunology
- medical and health sciences health sciences nutrition obesity
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2019
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
28006 MADRID
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.