Dissecting and Engineering Allosteric Activation in a Biosynthetic Enzyme

Project Information

DEAllAct

Grant agreement ID: 890562

DOI

10.3030/890562

Project closed

EC signature date 3 March 2020

Start date 16 November 2020

End date 15 November 2022

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost

€ 203 852,16

EU contribution

€ 203 852,16

Coordinated by

UPPSALA UNIVERSITET
Sweden

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (3)

Exploiting enzyme evolution for computational protein design

Author(s): Gaspar P. Pinto*, Marina Corbella*, Andrey O. Demkiv, Shina Caroline Lynn Kamerlin
Published in: Trends in Biochemical Sciences, Issue 5, 2022, Page(s) 375-389, ISSN 1362-4326
Publisher: Cell
DOI: 10.1016/j.tibs.2021.08.008

Allosteric rescue of catalytically impaired ATP phosphoribosyltransferase variants links protein dynamics to active-site electrostatic preorganisation

Author(s): Gemma Fisher, Marina Corbella, Magnus S. Alphey, John Nicholson, Benjamin J. Read, Shina C. L. Kamerlin, Rafael G. da Silva
Published in: Nature Communications, Issue 13, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-34960-9

Complex Loop Dynamics Underpin Activity, Specificity, and Evolvability in the (βα)8 Barrel Enzymes of Histidine and Tryptophan Biosynthesis

Author(s): Adrian Romero-Rivera*, Marina Corbella*, Antonietta Parracino, Wayne M. Patrick, and Shina Caroline Lynn Kamerlin
Published in: JACS Au, Issue 4, 2022, Page(s) 943-960, ISSN 2691-3704
Publisher: American Chemical Society
DOI: 10.1021/jacsau.2c00063

Other (2)

EVB Parameters for the Manuscript: Complex Loop Dynamics Underpin Activity, Specificity and Evolvability in the (Beta-Alpha)8 Barrel Enzymes of Histidine and Tryptophan Biosynthesis

Author(s): Romero-Rivera, Adrian; Corbella Morat��, Marina; Kamerlin, L.S.C.
Published in: 2022
Publisher: CERN
DOI: 10.5281/zenodo.5893598

Allosteric rescue of catalytically impaired ATP phosphoribosyltransferase variants links protein dynamics to active-site electrostatic preorganisation

Author(s): Fisher, Gemma; Corbella, Marina; Alphey, Magnus S.; Nicholson, John; Read, Benjamin J.; Kamerlin, Shina C. L.; de Silva, Rafael G.
Published in: 2022
Publisher: CERN
DOI: 10.5281/zenodo.7077771