Molecular insight into cellular uptake of choline
Choline is a key constituent of many cell membrane phospholipids and neurotransmitters such as acetylcholine. Transmembrane uptake of choline into eukaryotic cells involves the choline transporter-like (CTL) family of proteins, but it is poorly characterised. The key objective of the EU-funded CTL project is to bridge this scientific gap and investigate the function of CTL proteins. Through a combination of structural biology and biochemical characterisation techniques, scientists will decipher the molecular mechanism of cellular choline uptake. Given that CTL proteins are implicated in various diseases, the project's results will lay the foundation for future pharmacological studies.
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