Targeting Rab27A with covalent inhibitors for the treatment of metastatic breast cancer

Project Information

RabTarget4Metastasis

Grant agreement ID: 890900

DOI

10.3030/890900

Project closed

EC signature date 13 March 2020

Start date 1 August 2020

End date 29 October 2022

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost

€ 224 933,76

EU contribution

€ 224 933,76

Coordinated by

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (4)

Identification of the first structurally validated covalent ligands of the small GTPase RAB27A

Author(s): Mostafa Jamshidiha; Thomas Lanyon-Hogg; Charlotte L. Sutherell; Gregory B. Craven; Montse Tersa; Elena De Vita; Delia Brustur; Inmaculada Pérez-Dorado; Sarah Hassan; Rita Petracca; Rhodri M. Morgan; Máximo Sanz-Hernández; Jim C. Norman; Alan Armstrong; David J. Mann; Ernesto Cota; Edward W. Tate
Published in: RSC Medicinal Chemistry, Issue 26328682, 2022, Page(s) 150-155, ISSN 2632-8682
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1md00225b

A KLK6 Activity-Based Probe Reveals a Role for KLK6 Activity in Pancreatic Cancer Cell Invasion

Author(s): Leran Zhang; Scott Lovell; Elena De Vita; Pravin Kumar Ankush Jagtap; Daniel Lucy; Andrea Goya Grocin; Svend Kjær; Annabel Borg; Janosch Hennig; Aubry K. Miller; Edward W. Tate
Published in: Journal of the American Chemical Society, Issue 144, 2022, Page(s) 22493–22504, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.2c07378

A suite of activity-based probes to dissect the KLK activome in drug-resistant prostate cancer

Author(s): Scott Lovell; Leran Zhang; Thomas Kryza; Thomas Kryza; Anna Neodo; Nathalie Bock; Elena De Vita; Elizabeth D. Williams; Elisabeth Engelsberger; Congyi Xu; Alexander T Bakker; M. Maneiro; Reiko J. Tanaka; Charlotte L. Bevan; Judith A. Clements; Edward W. Tate; Edward W. Tate
Published in: Journal of the American Chemical Society, Issue 00027863, 2021, Page(s) 8911–8924, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1101/2021.04.15.439906

Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs)

Author(s): Qisi Zhang, Cyrille S. Kounde, Milon Mondal, Jake L. Greenfield, Jennifer R. Baker, Sergei Kotelnikov, Mikhail Ignatov, Christopher P. Tinworth, Leran Zhang, Daniel Conole, Elena De Vita, Dima Kozakov, Adam McCluskey, John D. Harling, Matthew J. Fuchter and Edward W. Tate
Published in: ChemComm, Issue 58, 2022, Page(s) 10933-10936, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2cc03092f