Seeing is believing: imaging of HIV binding with antibodies
Despite its widespread use in cell biology, conventional optical microscopy has a limited resolution of around 250 nm. As a result, its applicability to the study of viruses such as HIV, with a size of 120 nm, is limited. The EU-funded FILM-HIV project proposes to employ super-resolution fluorescence microscopy techniques to study viral cell entry and the mode of action of potent anti-HIV antibodies known to block this process. Given that HIV is one of the most lethal diseases of our times, causing around one million deaths globally every year, delineating its infection cycle is critical for the identification of novel therapeutic targets.
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