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Super-resolution quantitative imaging of HIV fusion and its neutralisation by antibodies

Project description

Seeing is believing: imaging of HIV binding with antibodies

Despite its widespread use in cell biology, conventional optical microscopy has a limited resolution of around 250 nm. As a result, its applicability to the study of viruses such as HIV, with a size of 120 nm, is limited. The EU-funded FILM-HIV project proposes to employ super-resolution fluorescence microscopy techniques to study viral cell entry and the mode of action of potent anti-HIV antibodies known to block this process. Given that HIV is one of the most lethal diseases of our times, causing around one million deaths globally every year, delineating its infection cycle is critical for the identification of novel therapeutic targets.

Call for proposal

H2020-MSCA-IF-2019
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Funding Scheme

MSCA-IF-EF-ST - Standard EF

Coordinator

LEIBNIZ-INSTITUT FUER PHOTONISCHE TECHNOLOGIEN E.V.
Address
Albert Einstein Strasse 9
07745 Jena
Germany
Activity type
Research Organisations
EU contribution
€ 162 806,40