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Exploring lamin-lipid interactions and the loss of nuclear structural integrity as the molecular determinants of human aging

Project description

Unravelling ageing mechanisms

As life expectancy increases, unravelling the mechanisms of ageing is crucial for providing quality of life for people aged 65 and older. The loss of nuclear integrity and the related flaws in nuclear mechanics are typical characteristics of ageing. In mammalian cells, the structural capacities of the nucleus are supported by the nuclear lamina, mainly lamin A (LA) and its interaction with the nuclear envelope. The EU-funded LipLAge project will explore how the interaction between LA and the inner nuclear membrane lipids influences nuclear lamina architecture and nuclear structural integrity during natural ageing. The project will apply an integrated lipid-driven molecular biophysics approach to study of the nuclear envelope during healthy human ageing.

Coordinator

INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES
Net EU contribution
€ 147 815,04
Address
Avenida Prof Egas Moniz
1649 028 Lisboa
Portugal

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Region
Continente Área Metropolitana de Lisboa Área Metropolitana de Lisboa
Activity type
Research Organisations
Non-EU contribution
€ 0,00