Immune system modulation after myocardial infarction
Current treatment strategies for ischaemic heart disease only ameliorate symptoms. The EU-funded MiNeMI project is working on a novel immunomodulatory approach that aims to regulate inflammation and promote heart regeneration after myocardial infarction. Researchers are developing a non-invasive microneedle-based skin patch loaded with both immunomodulatory and biological molecules. The idea is to release these therapeutics into the dermal layer of the skin where a reservoir of immune cells resides. The efficacy and safety of the MiNeMI approach will be tested in vitro and in an animal model of cardiac ischaemia.