Rational design of lipid cargo-carrier systems to enhance drug delivery
At all levels, biological systems enhance the efficiency of their many jobs through compartmentalisation accomplished largely with semi-permeable membranes. From the cell itself to numerous intracellular and extracellular vesicles and organelles used for trafficking 'materials' to the exact spot in which they are needed, separation of function is largely accomplished with the physical separation of the necessary 'ingredients'. The EU-funded QARGO project aims to harness the mechanisms of this amazing cellular encapsulation and trafficking machinery to develop lipid-based drug delivery systems. Although such systems have shown great potential, they cannot be fully exploited without rational design based on a deep understanding of the creation of functional lipid carriers in biological systems. QARGO is moving beyond trial and error to in silico solutions, enabling the rational design of cargo-carrier systems for therapeutics.
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