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Understanding the thermodynamic and mechanistic basis of a model biological temperature sensor

Project description

How biological temperature sensors work

Galilean thermometers – sealed tubes of liquid in which glass spheres float and sink with changes in ambient temperature – have been around for hundreds of years. Scientists, however, are still trying to figure out how biological temperature sensors work. The EU-funded BioTempSense project will study the physical mechanisms of temperature sensing of bacterial sodium channels, a model biological temperature sensor. It will use several approaches, including a bioinformatics and a molecular dynamics approach. It will also develop a coarse-grained computational model to allow transfer of the obtained results to other temperature sensors. The findings will deepen our understanding of the potential effect of an increase in global temperature on plants and animals. It will provide valuable insights into the design of pain therapeutics that target temperature-sensitive protein complexes in the human body.

Objective

Despite the existence of engineered thermometers since the time of Galileo, we still do not understand how biological temperature sensors work. Engineered thermometers take advantage of simple laws in which volume or electrical resistance vary linearly with temperature. Do similarly simple laws determine the temperature sensitivity of biological temperature sensors? The major objective of this project is to understand the physical mechanisms of temperature sensing of bacterial sodium channels, a model biological temperature sensor. To understand this mechanism three approaches will be taken: a bioinformatics approach to reveal any information evolution could tell us about the directed evolution of these sensors, a molecular dynamics approach to elucidate the molecular mechanism determining this temperature sensitivity, and finally the development of a coarse-grained computational model to allow transfer of the obtained results to other temperature sensors. A better understanding of biological temperature sensors has broad implications in the understanding of the potential effect of an increase in global temperature on plants and animals as well as in the design of pain therapeutics that target temperature-sensitive protein complexes in the human body. This highly interdisciplinary work is therefore expected to set the stage for improving the general understanding of biological temperature sensing, which, due to its relevance and wide-applicability, will subsequently enable to pursue my career as independent researcher.

Fields of science (EuroSciVoc)

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.

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Coordinator

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Net EU contribution
€ 162 806,40
Address
HOFGARTENSTRASSE 8
80539 Munchen
Germany

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Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Research Organisations
Links
Total cost
€ 162 806,40
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