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CORDIS

Mechanobiological optimization of regeneration in cell-enriched construct implants within degenerative Cartilages: a defect Repair method through restoring Energy AbsorpTION

Descripción del proyecto

Optimización mecanobiológica del tratamiento regenerador del cartílago

La artrosis afecta a la integridad mecánica del tejido, reduciendo su capacidad para absorber los golpes y minimizar los picos de carga a los que se someten los huesos subyacentes. Los métodos de ingeniería de tejidos proponen una solución a la artrosis mediante la implantación en el cartílago degenerativo de estructuras de andamiaje/hidrogel enriquecidas con condrocitos. El entorno mecánico de esta estructura celular desempeña un papel fundamental en la calidad y la cantidad de la matriz extracelular regenerada. El proyecto financiado con fondos europeos CREATION tiene por objeto recuperar la absorción de energía del cartílago degenerativo mediante la optimización de la regeneración en implantes de compuestos enriquecidos con células. El objetivo es desarrollar un armazón «in silico» para el modelado mecanobiológico de la estructura de implante cartilaginoso durante la carga. Seguidamente, el modelo se utilizará para reducir al mínimo las diferencias entre la absorción de energía de las estructuras de implante y el cartílago humano nativo.

Objetivo

Knee cartilage defects and consequent degeneration contribute to the development of osteoarthritis (OA). OA affects the mechanical integrity of the tissue, whose main function is to absorb shock and minimize peak loads in the underlying subchondral bone.
Tissue engineering methods propose solutions to OA by implanting chondrocyte cell-enriched hydrogel/scaffold constructs within degenerative cartilage defects. By applying mechanical loads to stimulate the cells within the constructs, they initiate cartilage extracellular matrix (ECM) synthesis. The mechanical environment of the cell-seeded construct has a crucial role in defining the quality and quantity of the regenerated ECM. This will determine the mechanical performance of the cartilage tissue. Indeed, any repair method has to aim at restoring the unique cartilage mechanics, in particular, the energy absorption capacity.
This project aims at restoring energy absorption of degenerative cartilage by optimizing regeneration in cell-enriched construct implants. The goal will be pursued by developing an in-silico framework for mechanobiological modelling of the regeneration and degeneration in the cartilage-implant compound during loading. Unique in the in-silico framework is the simultaneous modelling of regenerative and degenerative processes through adaptive modelling of the ECM. An innovative regeneration algorithm will be developed and integrated with a previously developed degeneration model. The adaptive model will then be used in an optimization scheme to minimize differences between energy absorption of construct implant and native human cartilage. An iterative performance evaluation is foreseen in comparison with biological experiments.
In collaboration with the participating research groups and using my background, I will have a unique chance to take a step forward in furthering insights on OA disease process. The anticipated collaborations and training will contribute to making me a mature researcher.

Coordinador

KATHOLIEKE UNIVERSITEIT LEUVEN
Aportación neta de la UEn
€ 178 320,00
Dirección
OUDE MARKT 13
3000 Leuven
Bélgica

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Región
Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven
Tipo de actividad
Higher or Secondary Education Establishments
Enlaces
Coste total
€ 178 320,00