Periodic Reporting for period 1 - METACYL (Catalytic META C-H ACYLation of arenes)
Reporting period: 2020-11-16 to 2022-11-15
The exploitation of the cooperative catalysis (palladium and norbornene) for the synthesis of complex organic architectures and the selective functionalization of remote C-H bonds has been demonstrated. In particular, the selective installation of acyl groups (esters, amides, acids) in less favorable positions, which is a common challenging task, has been here achieved. The results of this project will be highly useful for the development of new advanced organic syntheses and new efficient catalytic systems both in academia and industry to access pharmaceutical intermediates, fine chemicals and organic materials.
Impact for the fellow
The METACYL project demonstrated to be an excellent platform for the consolidation of the ER career. The ER improved his expertise in organic synthesis, catalysis, carbonylation reactions as well as in mentoring, project leading and management. The ER contributed to the preparation of high impact articles stimulating his independence and initiative skills. The provided high-level training programme of METACYL has significantly improved the career prospects of the ER by nurturing and promoting scientific rigor, excellence, problem solving aptitude, interdisciplinary and creativity. The training received during the fellowship and the close mentoring provided by the supervisor has contributed to enhance the ability of the fellow to effectively communicate with colleagues from different backgrounds and settings (e.g. chemical engineering), which will be a great advantage for his subsequent professional development.