Project description
Moving liquid-assisted grinding to the commercial stage
Mechanochemistry using manual grinding or ball mill equipment is an attractive and sustainable alternative to traditional solution methods for synthesising composite solids. Using small volumes of water, liquid-assisted grinding can accelerate the kinetics reactions between different solids. The EU-funded GrindCore project aims to provide further insight into the reaction mechanisms that take place on a molecular level during liquid-assisted grinding. Researchers plan to monitor the real-time kinetic reactions of an organic compound called methylcyclohexane through advanced X-ray diffraction and Raman spectroscopy techniques. The project's results could help take this technology faster to the commercial stage. Liquid-assisted grinding produces novel solids with bespoke physical and chemical properties that can be used by the pharmaceutical industry to screen for new drugs.
Objective
Liquid-assisted grinding (LAG) is a mechanochemical process in which a catalytic amount of added liquid tremendously accelerate the reaction kinetics, and often significantly alter reaction outcome. Due to high applicability potential of LAG and still a huge amount of ambiguities, it has become essential to improve understanding of reaction mechanisms at molecular level. Establishing a correspondence between solution and solid-state reaction mechanisms would enable utilisation of huge body of knowledge in the currently barely grazed mechanistic framework of solid-state milling reactions, which is a prerequisite for their systematic use and utilisation in Green Chemistry synthetic alternatives, which would be a critical requirement for any industrial application of LAG. This project should contribute implementation of MCh for a cleaner chemical laboratory and a sustainable, low-waste and low-emissions chemical and pharmaceutical industry. It is unacceptable that further development of such an important methodology depends on a mere trial and error or, at best, on the experimenter's experience and instincts.
Here, recently developed techniques for in situ real-time monitoring of MCh reactions by X-ray diffraction and Raman spectroscopy will be employed to enable insight into uninterrupted reactions and thus resolution of mechanistic pathways and kinetics of the selected representative simple reactions. The obtained data will be interpreted with respect of properties of liquids added to LAG systems. It is expected that in this way the catalytic action of liquids in LAG reactions will be put to a firmer ground.
The accumulated fundamental understanding of LAG reactions will be then applied to develop or improve Green Chemistry procedures for selected environmentally relevant processes and materials. This should consequently lead to optimisation of these processes, setting them ready for scale-up to ecologically friendlier, sustainable industrial processes.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
See all projects funded under this programme -
H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2019
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
10000 Zagreb
Croatia
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.