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Nanoscale organisation of axo-axonic synapses along the axon initial segment of cortical pyramidal neurons in health and disease.

Project description

Molecular organisation and excitability in neurons

Neurons in the brain possess the remarkable capacity of integrating thousands of different inputs into a single action potential down the axon. However, the local organisation and interplay of proteins responsible for neuron excitability has not been fully elucidated. The EU-funded Nano-axo-syn project will employ super-resolution microscopy and electrophysiology to characterise the organisation of molecules responsible for input integration and decipher its impact on neuronal excitability. Using a mouse model of schizophrenia, scientists will study potential structural modifications and how they affect neuronal output and neuronal transmission in health and disease.

Call for proposal

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WC2R 2LS London
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 212 933,76