Molecular organisation and excitability in neurons
Neurons in the brain possess the remarkable capacity of integrating thousands of different inputs into a single action potential down the axon. However, the local organisation and interplay of proteins responsible for neuron excitability has not been fully elucidated. The EU-funded Nano-axo-syn project will employ super-resolution microscopy and electrophysiology to characterise the organisation of molecules responsible for input integration and decipher its impact on neuronal excitability. Using a mouse model of schizophrenia, scientists will study potential structural modifications and how they affect neuronal output and neuronal transmission in health and disease.
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