Understanding the mechanisms modulating risk and resilience of mental disorders
Some people thrive in the face of adversity and are able to maintain healthy mental and physical performance. Others lack the ability to cope with critical situations. This Marie Skłodowska-Curie Actions Standard European Individual Fellowship aims to revolutionise our understanding of the heterogeneous mechanisms modulating risk and resilience of mental disorders. The EU-funded ToPP project will expand the innovative normative modelling framework to incorporate information on degree of genetic relatedness (genetic normative model). It will describe the distance of each individual in reference to the empirical population/healthy norm of a biological process. This distance will be computed while incorporating information on relatedness quantified by bioinformatic tools based on single-nucleotide polymorphisms across the genome or familiar relationships.