A molecular atlas of breast cancer
Harnessing the patient's own immune system to fight cancer is emerging as a promising therapeutic strategy. However, the limited efficacy of immunotherapies to treat breast cancer has spurred great interest. To investigate this, the EU-funded SCISSORS project proposes to employ single-cell genomics to study how the immune system responds to the evolving tumour as it emerges from the healthy tissue. Scientists will develop a computational model that integrates multiple aspects of breast cancer, including normal to malignant transition, interplay of breast and immune cells and tumour clonal dynamics. Apart from offering fundamental insight into cancer biology, the project's findings may reveal new progression markers and improve risk stratification.