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Single cell profiling of breast tumors and the residing immune cells leveraged by integration with multi-dimensional molecular data from thousands of tumors

Project description

A molecular atlas of breast cancer

Harnessing the patient's own immune system to fight cancer is emerging as a promising therapeutic strategy. However, the limited efficacy of immunotherapies to treat breast cancer has spurred great interest. To investigate this, the EU-funded SCISSORS project proposes to employ single-cell genomics to study how the immune system responds to the evolving tumour as it emerges from the healthy tissue. Scientists will develop a computational model that integrates multiple aspects of breast cancer, including normal to malignant transition, interplay of breast and immune cells and tumour clonal dynamics. Apart from offering fundamental insight into cancer biology, the project's findings may reveal new progression markers and improve risk stratification.

Coordinator

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Net EU contribution
€ 224 933,76
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
United Kingdom

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Region
East of England East Anglia Cambridgeshire CC
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00