Investigating CAusal Relations IN Gene-environment interactions in children exposed to war-related Traumatic events.

Informations projet

CARINGTrauma

N° de convention de subvention: 896021

DOI

10.3030/896021

Projet clôturé

Date de signature de la CE 20 Avril 2020

Date de début 14 Septembre 2020

Date de fin 13 Septembre 2022

Financé au titre de

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coût total

€ 224 933,76

Contribution de l’UE

€ 224 933,76

Coordonné par

QUEEN MARY UNIVERSITY OF LONDON
United Kingdom

Periodic Reporting for period 1 - CARINGTrauma (Investigating CAusal Relations IN Gene-environment interactions in children exposed to war-related Traumatic events.)

Période du rapport: 2020-09-14 au 2022-09-13

Résumé du contexte et des objectifs généraux du projet

Refugee children that have experienced traumatic situations are at increased risk of developing psychological disturbances. While some refugee children develop emotional and behavioural disorders (post-traumatic stress disorder, anxiety, or depression, for example), others exhibit remarkable resilience. This variability is linked to the complex interplay between individual traits, such as genetic factors, and characteristics of the environment. The EU-funded CARINGTrauma project developed an innovative statistical approach to explore the complex and interactive causal relations between the various determinants of mental health across multiple domains. It used a unique dataset from a large study of Syrian refugee children and their caregivers (BIOPATH). The data analyzed included demographic, genetic, social, psychological, and environmental variables, allowing a comprehensive evaluation of the causal determinants of mental health of refugee children. We found that daily stressors are important determinants of refugee children's mental health and that the level of exposure to war events, violence re-victimization and caregiver mental health are particularly relevant causal determinants for severe and persistent psychological problems.

Travail effectué depuis le début du projet jusqu’à la fin de la période considérée dans le rapport et principaux résultats atteints jusqu’à présent

An integrative statistical approach to exploring causal relationships in non-experimental data was developed, systematically evaluated, and made publicly available. This new statistical tool was first applied to a well-established large cohort in the UK revealing the most relevant psychological and environmental factors in the first year of life that causally predict cognitive abilities at the beginning of school life. The same approach was then applied to discover the main psychosocial causes of severe and persistent psychological distress in Syrian refugee children. The level of exposure to war-related events, bullying in the community, and maltreatment emerged as causal factors for severe forms of post-traumatic stress disorder in children. Finally, the CARINGTrauma project explored the use of genetic liability measures (i.e. polygenic scores) to improve causal investigations on refugee children's mental health. The results were presented at various international conferences and webinars, and are publicly available in preprint repositories.

Progrès au-delà de l’état des connaissances et impact potentiel prévu (y compris l’impact socio-économique et les conséquences sociétales plus larges du projet jusqu’à présent)

The new integrative modeling approach to explore causal relationships in observational data adds to researchers' toolbox and helps them tackling causal questions in child development and mental health. Results on the causal predictors of severe mental health problems in Syrian refugee children can potentially inform preventive strategies, services, and mental health care planning for children affected by war and living in challenging conditions. Finally, new mechanistic insights and improved causal predictions for mental health problems are expected to be achieved by including genetic factors in the integrative statistical modeling approach.

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