An engineered skin model for studying Dengue virus infection
Dengue is a viral disease transmitted by arthropods such as mosquitoes, and it poses a significant threat in tropical and subtropical regions of the world. There is a lack of experimental systems for studying Dengue arbovirus pathogenesis, hampering biomedical advances. Scientists of the EU-funded VirIVITES project propose to develop an in vitro Dengue arbovirus infection model based on tissue-engineered human skin. The model will comprise immune cells, sensory nerve cells and naturally infected mosquitoes. It will serve to investigate infection and cell responses to the Dengue arbovirus. Using this model, scientists hope to develop new strategies for preventing or treating arbovirus-associated neurological symptoms.
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