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Ongoing chromosomal instability in cancer: real-time imaging and single cell genetics of missegregating chromosomes.

Project description

Real-time study of chromosomal instability in cancer

Many genomic aberrations originate from mistakes during cell division, in which the DNA is normally divided equally to both daughter cells. There is a lack of understanding regarding the genetic consequences of mitotic errors for tumourigenesis and genomic instability. Patient-derived tumour organoids and cutting-edge research technologies combining direct microscopic observation of mitosis and single-cell whole-genome sequencing provide an opportunity to study these fundamental questions. The EU-funded OCIC project will study the occurrence and maintenance of genomic instability using organoids derived from esophageal adenocarcinoma (EAC) patients as a model system. The EAC genomes, in particular, show genomic catastrophes that might drive tumourigenesis. Ultimately, the study aims to apply the technology to a panel of human tumour organoids derived from different tissues.

Call for proposal

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Heidelberglaan 100
3584 CX Utrecht

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Activity type
Higher or Secondary Education Establishments
EU contribution
€ 187 572,48