Project description
Cell senescence in leukaemia
Cellular ageing is a complex process associated with the gradual functional decline of organs and systems. Delineating the mechanisms underlying age-related changes such as accelerated cellular senescence and aberrant epigenetic regulation is paramount for understanding how cancer develops. The scope of the EU-funded SENAGE project is to study the epigenetic profile of chronic lymphocytic leukaemia and acute myeloid leukaemia cells and correlate it to cell senescence. The idea is to unravel why older patients are at higher risk of developing these types of leukaemias. Scientists will also unveil new target molecules for treatment and prevention and test existing senolytic drugs known to induce apoptosis in senescent cells.
Objective
Cancer is a major public health problem and one of the leading causes of death worldwide. In particular, it has been the second cause of death in Spain, Europe and United States. Although cancer can occur at any age, aging is one of the main risk factors for its development. Aging is a complex scarcely understood multi-step process associated with the gradual functional decline of organs and systems. In addition, age-dependent changes in epigenetic regulation occur, indicating that epigenetic regulation may also play an important role in aging. Similar changes have been observed at the cellular level in a mechanism known as senescence. This mechanism is a cellular response that limits the proliferation of aged or damaged cells, behaving as a tumor suppressor mechanism and transformation events lead to escape from it.
Chronic lymphocytic leukemia and acute myeloid leukemia are the most frequent types of leukemias and have median ages at diagnosis of 68 years. Both have a low incidence in the young population and increase with age. Thus, it is important to explore novel approaches to understand the mechanisms of aging favoring these types of leukemias, thereby unraveling new target molecules for treatment and prevention. We propose to explore the senescence epigenetic profile in leukemic cells, the impact of senolytic drugs in patients and in the development of AML in spontaneous animal model. The approach will bridge cancer epigenetics with senescence, aging and leukemogenesis.
This proposal will augment my scientific knowledge and practical skills. In addition, the complementary planned activities of the action will provide me to the additional tools to become an independent investigator in the near future.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences public health
- medical and health sciences clinical medicine oncology leukemia
- medical and health sciences basic medicine physiology homeostasis
- natural sciences biological sciences genetics epigenetics
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2019
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
08916 Badalona
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.