Metabolic regulation of reciprocal signalling between skeletal muscle cell types

Project description

Gaining unique insight into the myofiber to MuSC signalling

Maintenance of skeletal muscle quantity and quality is facilitated by remarkable tissue plasticity. Muscle-resident stem cells (MuSC) contribute to this plasticity by the differentiation and subsequent fusion with the myofiber in the process called myonuclear accretion. The progression of this process is characterised by distinct MuSC metabolic requirements and depends on the myofiber metabolic state. The EU-funded MUSIC project aims to decipher the role of the metabolic regulator AMPKalpha2 in MuSC signalling. Furthermore, the research will initiate an interdisciplinary collaboration to perform integrative phosphoproteomic and metabolomic analyses to get a unique insight into the myofiber to MuSC signalling.

Fields of science

• medical and health sciences › medical biotechnology › cells technologies › stem cells

Keywords

• Skeletal muscle regeneration
• Plasticity
• Cellular cross-talk
• Myogenesis
• Myonuclear accretion
• Satellite cells

Programme(s)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Topic(s)

• MSCA-IF-2019 - Individual Fellowships

Call for proposal

H2020-MSCA-IF-2019

See other projects for this call

Funding Scheme

MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)

Coordinator

UNIVERSITE LYON 1 CLAUDE BERNARD

Net EU contribution

€ 184 707,84

Address

Boulevard Du 11 Novembre 1918 Num43
69622 Villeurbanne Cedex
France

Region

Auvergne-Rhône-Alpes › Rhône-Alpes › Rhône

Activity type

Higher or Secondary Education Establishments

Links

Other funding

€ 0,00