Gaining unique insight into the myofiber to MuSC signalling
Maintenance of skeletal muscle quantity and quality is facilitated by remarkable tissue plasticity. Muscle-resident stem cells (MuSC) contribute to this plasticity by the differentiation and subsequent fusion with the myofiber in the process called myonuclear accretion. The progression of this process is characterised by distinct MuSC metabolic requirements and depends on the myofiber metabolic state. The EU-funded MUSIC project aims to decipher the role of the metabolic regulator AMPKalpha2 in MuSC signalling. Furthermore, the research will initiate an interdisciplinary collaboration to perform integrative phosphoproteomic and metabolomic analyses to get a unique insight into the myofiber to MuSC signalling.