Project description
Insight into the epigenetic profile of motor neuron disorders
Motor neuron disorders (MND), comprising spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS), are a group of devastating diseases mainly manifested by motor neuron degeneration. Emerging evidence suggests that disease severity is modulated through epigenetics in which DNA methylation plays a dominant role. The scope of the EU-funded MANTIS project is to uncover the epigenetic mechanism gone awry in MND. Leveraging cutting-edge techniques from next-generation sequencing to single-cell mass cytometry and patient-derived iPSCs, the scientists will explore the role of the ten-eleven translocation (TET) enzymes. In DNA methylation, TETs are responsible for balancing the hydroxymethylated cytosines (5hmC) to favor gene expression. The therapeutic potential of demethylation will also be explored to correct the epigenetic profile and restore the disrupted gene expression.
Fields of science
- natural sciencesbiological sciencesgeneticsDNA
- medical and health sciencesbasic medicinephysiologypathophysiology
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes
- medical and health sciencesbasic medicineneurologyamyotrophic lateral sclerosis
- natural sciencesbiological sciencesgeneticsepigenetics
Programme(s)
Funding Scheme
MSCA-IF-EF-RI - RI – Reintegration panel
Coordinator
75654 Paris
France
See on map