Composition and dynamics of stress granules in cerebral organoid models of frontotemporal dementia

Project description

An in vitro 3D model of dementia

Patients suffering from frontotemporal dementia (FTD) present with degeneration in the frontal and temporal lobes of the brain associated with the formation of protein aggregates. Given the lack of FTD treatments today, the EU-funded FTD-Organoids project will employ 3D brain organoid cultures grown from embryonic stem cells as the first in vitro cerebral model of FTD. Scientists will characterise this model at the cellular and molecular level and investigate the mechanisms underlying FTD pathophysiology. The project's results have the potential to identify novel FTD targets for the development of therapeutic interventions.

Field of science

• /natural sciences/biological sciences/genetics and heredity/rna
• /natural sciences/biological sciences/biochemistry/biomolecules/proteins
• /medical and health sciences/medical biotechnology/cells technologies/stem cells
• /medical and health sciences/basic medicine/neurology

Programme(s)

• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Topic(s)

• MSCA-IF-2019 - Individual Fellowships

Call for proposal

H2020-MSCA-IF-2019
See other projects for this call

Funding Scheme

MSCA-IF-EF-SE - Society and Enterprise panel

Coordinator

INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH

Address

Dr Bohrgasse 3
1030 Wien
Austria

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

EU contribution

€ 174 167,04