THIODIV sought to explore how sulfenyl groups can be used to exert control over catalytic processes based on alkynes and gold catalysis. The approach was planned to provide access into new chemical motifs as well as understanding of reactivity. In doing so it would underpin further advances in the field while delivering new methodology to enable synthetic chemistry of complex molecules.
THIODIV has developed effective new synthetic methods. Effective preparation of the desired reaction substrates, that had not previously been used, has been achieved in a way that allows for modification at different positions. Four new catalysis based methods have been developed in THIODIV and each has been studied in terms of reaction optimisation, substrate scope and applications of the catalysis products. As a result we understand which factors that affect reaction pathways, from structure to reaction conditions, and the ways in which we might use those methods via as a detailed exploration of the underpinning chemistry. Extensive optimization studies were run along with structure-reactivity and structure-scope studies. Mechanistic studies support the reactivity hypothesis. A particular advance is the ability take the same type of substrates and using different conditions access two different product outcomes which gives synthetic chemists significant control.
The project was impacted by the limitations associated with the overlapping period of lockdown and social distancing affecting the in-lab time and efficiency that could be achieved, but overall THIODIV has achieved its goals using the planned approach to deliver effective new methods, and to understand scope and limitations and impact of sulfenyl groups on gold catalysis.
Dissemination of the results is underway with two manuscripts in preparation that in due course will be advertised via social media and web-pages as well as in presentations by the host group. The fellow has given presentations at academic and industrial locations over the course of the project advertising the fellowship. Furthermore an outreach activity that the fellow was integral to a key part of, and which involves a secondary education institute, an international company and the host university is planned for separate publication.
Conclusions: The support from the MSC Fellowship has allowed the development of several new synthetic methodology's that provide tools and understanding to advance synthetic organic chemistry enabling those areas that depend on it. By enabling greater understanding, and more sustainable methods this work contributes to society's need for sustainable use of limited natural resources. Furthermore it has provided the fellow with the training needed to expand his skills and knowledge, in new areas of science to him as well as the allied transferable areas vital to being a future research leader. The postdoctoral fellow has secured a scientific position at a leading international company on the basis of his achievements and training in THOIDIV.
