SmartHeart: 3D heart model to aid drug discovery
During the drug discovery process, drugs under development are initially tested on animal models. However, there is an overall consensus to reduce animal experiments as much as possible, replacing them with in vitro models of disease. With this in mind, the EU-funded SmartHeart project is working on an innovative 3D in vitro cardiac assay that employs induced pluripotent stem cell-derived cardiomyocytes grown in a microstructured gel. The SmartHeart assay will allow the qualitative and quantitative measurement of several cardiac parameters as well as the sub-cellular structure observation via high resolution imaging techniques. The technology will be available in multi-well format suitable for high throughput screening processes.
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