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Functional Lipid−Protein Interactions in Integral Membrane Proteins


Cryo-EM structure of the human Kv3.1 channel reveals gating control by the cytoplasmic T1 domain

Author(s): Gamma Chi, Qiansheng Liang, Akshay Sridhar, John B. Cowgill, Kasim Sader, Mazdak Radjainia, Pu Qian, Pablo Castro-Hartmann, Shayla Venkaya, Nanki Kaur Singh, Gavin McKinley, Alejandra Fernandez-Cid, Shubhashish M. M. Mukhopadhyay, Nicola A. Burgess-Brown, Lucie Delemotte, Manuel Covarrubias, Katharina L. Dürr
Published in: Nature Communications, Issue 13, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-29594-w

Structural and dynamic mechanisms of GABAA receptor modulators with opposing activities

Author(s): Shaotong Zhu, Akshay Sridhar, Jinfeng Teng, Rebecca J. Howard, Erik Lindahl, Ryan E. Hibbs
Published in: Nature Communications, Issue 13, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-32212-4

Regulation of a pentameric ligand-gated ion channel by a semiconserved cationic lipid-binding site

Author(s): Akshay Sridhar, Sarah C. R. Lummis, Diletta Pasini, Aujan Mehregan, Marijke Brams, Kumiko Kambara, Daniel Bertrand, Erik Lindahl, Rebecca J. Howard, Chris Ulens
Published in: Journal of Biological Chemistry, Issue 297, 2021, Page(s) 100899, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2021.100899

Markov State Modelling Reveals Heterogeneous Drug-Inhibition Mechanism of Calmodulin

Author(s): Annie M. Westerlund, Akshay Sridhar, Leo Dahl, Alma Andersson, Anna-Yaroslava Bodnar, Lucie Delemotte
Published in: PLOS Computational Biology, Issue 1553734X, 2022, ISSN 1553-734X
Publisher: Public Library of Science
DOI: 10.1371/journal.pcbi.1010583

Subtype-specific modulation of human KV 7 channels by the anticonvulsant cannabidiol through a lipid-exposed pore-domain site

Author(s): Michael Pökl, Akshay Sridhar, Damon J. A. Frampton, Veronika A. Linhart, Lucie Delemotte, Sara I. Liin
Published in: British Journal of Pharmacology, 2023, ISSN 0007-1188
Publisher: Wiley-Blackwell
DOI: 10.1111/bph.16183

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