Functional Lipid−Protein Interactions in Integral Membrane Proteins

Project Information

Lipopeutics

Grant agreement ID: 898762

DOI 10.3030/898762

Project closed

EC signature date 8 April 2020

Start date 1 November 2020

End date 31 October 2022

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 191 852,16

EU contribution € 191 852,16

Coordinated by

KUNGLIGA TEKNISKA HOEGSKOLAN
Sweden

Publications

Peer reviewed articles (6)

Cryo-EM structure of the human Kv3.1 channel reveals gating control by the cytoplasmic T1 domain

Author(s): Gamma Chi, Qiansheng Liang, Akshay Sridhar, John B. Cowgill, Kasim Sader, Mazdak Radjainia, Pu Qian, Pablo Castro-Hartmann, Shayla Venkaya, Nanki Kaur Singh, Gavin McKinley, Alejandra Fernandez-Cid, Shubhashish M. M. Mukhopadhyay, Nicola A. Burgess-Brown, Lucie Delemotte, Manuel Covarrubias, Katharina L. Dürr
Published in: Nature Communications, Issue 13, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-29594-w

Functional and structural insights into activation of TRPV2 by weak acids

Author(s): Ferdinand M Haug, Ruth A Pumroy, Akshay Sridhar, Sebastian Pantke, Florian Dimek, Tabea C Fricke, Axel Hage, Christine Herzog, Frank G Echtermeyer, Jeanne de la Roche, Adrian Koh, Abhay Kotecha, Rebecca J Howard, Erik Lindahl, Vera Moiseenkova-Bell, Andreas Leffler
Published in: The EMBO Journal, Issue 43, 2024, Page(s) 2264-2290, ISSN 1460-2075
Publisher: Nature Publishing Group
DOI: 10.1038/s44318-024-00106-4

Structural and dynamic mechanisms of GABAA receptor modulators with opposing activities

Author(s): Shaotong Zhu, Akshay Sridhar, Jinfeng Teng, Rebecca J. Howard, Erik Lindahl, Ryan E. Hibbs
Published in: Nature Communications, Issue 13, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-32212-4

Regulation of a pentameric ligand-gated ion channel by a semiconserved cationic lipid-binding site

Author(s): Akshay Sridhar, Sarah C. R. Lummis, Diletta Pasini, Aujan Mehregan, Marijke Brams, Kumiko Kambara, Daniel Bertrand, Erik Lindahl, Rebecca J. Howard, Chris Ulens
Published in: Journal of Biological Chemistry, Issue 297, 2021, Page(s) 100899, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2021.100899

Markov State Modelling Reveals Heterogeneous Drug-Inhibition Mechanism of Calmodulin

Author(s): Annie M. Westerlund, Akshay Sridhar, Leo Dahl, Alma Andersson, Anna-Yaroslava Bodnar, Lucie Delemotte
Published in: PLOS Computational Biology, Issue 1553734X, 2022, ISSN 1553-734X
Publisher: Public Library of Science
DOI: 10.1371/journal.pcbi.1010583

Subtype-specific modulation of human KV 7 channels by the anticonvulsant cannabidiol through a lipid-exposed pore-domain site

Author(s): Michael Pökl, Akshay Sridhar, Damon J. A. Frampton, Veronika A. Linhart, Lucie Delemotte, Sara I. Liin
Published in: British Journal of Pharmacology, 2023, ISSN 0007-1188
Publisher: Wiley-Blackwell
DOI: 10.1111/bph.16183