Functional Lipid−Protein Interactions in Integral Membrane Proteins

Project description

Trans-membrane domains as novel drug targets

Membrane proteins constitute important drug targets against many diseases. However, the nature of the ligand binding sites on these proteins limits the specificity of the drugs, leading to many side effects. Emerging evidence on the interaction of trans-membrane domains (TMD) with plasma membrane lipids has led researchers of the EU-funded Lipopeutics project to investigate the potential of targeting these parts of the proteins with allosteric drugs. Using molecular dynamics simulations, the project will identify specific lipid binding sites within TMDs and design compounds capable of binding within the hydrophobic TMD pocket, stabilising the functional state of the protein.

Programme(s)

• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Topic(s)

• MSCA-IF-2019 - Individual Fellowships

Call for proposal

H2020-MSCA-IF-2019
See other projects for this call

Funding Scheme

MSCA-IF-EF-ST - Standard EF

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Coordinator

KUNGLIGA TEKNISKA HOEGSKOLAN

Address

Brinellvagen 8
100 44 Stockholm
Sweden

Activity type

Higher or Secondary Education Establishments

EU contribution

€ 191 852,16