Trans-membrane domains as novel drug targets
Membrane proteins constitute important drug targets against many diseases. However, the nature of the ligand binding sites on these proteins limits the specificity of the drugs, leading to many side effects. Emerging evidence on the interaction of trans-membrane domains (TMD) with plasma membrane lipids has led researchers of the EU-funded Lipopeutics project to investigate the potential of targeting these parts of the proteins with allosteric drugs. Using molecular dynamics simulations, the project will identify specific lipid binding sites within TMDs and design compounds capable of binding within the hydrophobic TMD pocket, stabilising the functional state of the protein.
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