Project description DEENESFRITPL The safety of non-nutritive sweeteners as a substitute for sugar Leading health agencies around the world are currently promoting the consumption of products containing non-nutritive sweeteners (NNS) as healthy alternatives to products sweetened with added sugar. However, recent studies have demonstrated an increased risk for total and cardiovascular disease mortality in people consuming at least two beverages containing NNS per day. Animal studies also indicate that NNS have the potential to disrupt normal metabolic and vascular function, which are essential in the development of obesity, insulin resistance and cardiovascular disease. The EU-funded SWEETENED HEARTS project aims to assess the metabolic and vascular effects of consuming NNS habitually in humans via a prospective, placebo-controlled, randomised, three-period crossover study to provide conclusive information for policymakers about the safety of NNS. Show the project objective Hide the project objective Objective In an effort to reduce the incidence of obesity, type 2 diabetes and cardiovascular disease, leading health agencies around the world are currently promoting the consumption of food and beverages containing non-nutritive sweeteners (NNS), advocating them as healthy alternatives to products sweetened with added sugars. As the harmful health effects of excess sugar consumption are often attributed to the high-energy content of added sugar, it has been assumed that NNS are physiologically inactive simply because they have little to no energy content. Recent evidence, however, demonstrates an increased risk in total and cardiovascular disease mortality in people consuming at least two NNS-sweetened beverages per day. While these findings are interesting, they are difficult to interpret as NNS are typically consumed more often by those whose cardiometabolic health is already compromised. Despite this, evidence from animal studies, including that delivered by our own consortium, indicate that NNS have the potential to disrupt normal metabolic and vascular function, events that are primary in the development of obesity, insulin resistance and cardiovascular disease. Indeed, rather than benefiting us, the impact of consuming NNS may be as bad on human health as the effects of excess sugar consumption. To bridge the findings from epidemiological and experimental research, this Standard EF will, for the first time in vivo, in humans, assess the metabolic and vascular effects of consuming NNS habitually; via a prospective, placebo-controlled, randomized, three-period crossover study. This research will also provide information about the role of type 1 sweet taste receptors (T1Rs), as well as oral sweet taste perception, in any potential NNS-mediated vascular/metabolic dysfunction. Ultimately, the findings from this research will inform policy makers about the safety of NNS, with the potential to lobby health authorities to revisit the regulatory status of these substances. Fields of science engineering and technologyother engineering and technologiesfood technologysocial sciencessociologydemographymortalitymedical and health sciencesclinical medicineendocrinologydiabetesmedical and health sciencesclinical medicinecardiologycardiovascular diseasesmedical and health scienceshealth sciencesnutritionobesity Keywords non-nutritive sweeteners artificial sugars vascular reactivity vascular function vascular dysfunction metabolism cardiovascular disease obesity insulin resistance Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Topic(s) MSCA-IF-2019 - Individual Fellowships Call for proposal H2020-MSCA-IF-2019 See other projects for this call Funding Scheme MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF) Coordinator UNIVERSITE GRENOBLE ALPES Net EU contribution € 196 707,84 Address 621 AVENUE CENTRALE 38058 Grenoble France See on map Region Auvergne-Rhône-Alpes Rhône-Alpes Isère Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 196 707,84