Project description
Tracing toxicity during ozonation of wastewater
High concentrations of organic micropollutants (MPs) can have adverse effects on the aquatic environment, potentially polluting important drinking water sources. Since MPs can enter watercourses through conventional wastewater treatment plants, many EU countries have been forced to upgrade their facilities. While ozonation technology can reduce certain toxicities, toxicological studies detected mutagenetic and genotoxic activities (associated with carcinogenicity) in ozonated wastewater. Meanwhile, little is known about the nature of mutagenetic and genotoxic ozonation products (OTPs) and by-products (OBPs). The EU-funded OzoToxID project will develop and apply an integrative bioanalytical strategy combining mutagenicity and genotoxicity bioassays, fractionation and innovative high-resolution mass spectrometry chemical analysis to detect mutagenetic and genotoxic OTPs and OBPs, define their precursors and elucidate their formation processes.
Objective
Organic micropollutants (MPs) such as pharmaceuticals, industrial chemicals, and biocides cause undesired effects in the aquatic environment when present above certain concentrations. Conventional wastewater treatment plants (WWTPs) are major point sources of entry of MPs into watercourses, leading to disturbances in the ecosystems of receiving water bodies and potentially to a negative impact on the quality of drinking water resources. Several European countries have started upgrading their WWTPs to reduce discharges of MPs into water bodies. Ozonation is one of the two main technologies used to upgrade WWTPs. The abatement of MPs by ozone has been shown to reduce certain toxicities such as endocrine disruption and algal toxicity. However, toxicological studies which investigated mutagenicity and genotoxicty –two endpoints relevant to carcinogenicity– revealed that ozonated wastewater exhibited mutagenic and genotoxic activities, which were not present before ozonation. To date, the nature of mutagenic and genotoxic ozonation transformation products and byproducts (OTPs and OBPs) as well as their precursors has not been elucidated. Owing to the large number of MPs present in wastewater effluents, testing each compound individually is not a feasible option. Consequently, an integrative strategy that prioritizes identification and targets the mutagenic and genotoxic compounds after toxicity assessment is necessary. OzoToxID aims at developing and implementing an integrative bioanalytical strategy based on effect-directed analysis combining mutagenicity and genotoxicity bioassays, fractionation, and cutting-edge high-resolution mass spectrometry chemical analysis to identify mutagenic and genotoxic OTPs/OBPs, determine their precursors, and elucidate their formation pathways. OzoToxID will provide key data that is crucial to determine the feasibility of ozonation when upgrading WWTPs.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology environmental engineering water treatment processes drinking water treatment processes
- engineering and technology environmental engineering water treatment processes wastewater treatment processes
- natural sciences earth and related environmental sciences hydrology
- natural sciences biological sciences ecology ecosystems
- natural sciences chemical sciences analytical chemistry mass spectrometry
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2019
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
8600 Dubendorf
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.