Project description
Complement factor H-related proteins and their role in pathogenesis
Complement factor H (FH) and FH-related (FHR) proteins are associated with systemic and organ-specific pathologies including impaired defense against infections and incurable renal, eye and autoimmune diseases. While the biological function of FH is well-defined, the function of the other six highly homologous FHR proteins is mostly unknown, as is their role in the disease-specific pathogenic mechanisms. The EU-funded SciFiMed project will study the FH family proteins' contributions in health and disease aiming to obtain proof-of-principle for a multiplex detection system to simultaneously quantify and analyse the functional activity of all seven proteins in patient samples. This high-impact project will enable new product developments and provide new perspectives for patient treatments.
Field of science
- /natural sciences/biological sciences/biochemistry/biomolecules/proteins
- /medical and health sciences/basic medicine/immunology
Programme(s)
Call for proposal
H2020-FETOPEN-2018-2019-2020-01
See other projects for this call
Funding Scheme
RIA - Research and Innovation action
Coordinator
35037 Marburg
Germany
Participants (8)
93053 Regensburg
28040 Madrid
1006 AN Amsterdam
1053 Budapest
9713 GZ Groningen
5405 PB Uden
82347 Bernried
Participation ended
93053 Regensburg
