Project description DEENESFRITPL Complement factor H-related proteins and their role in pathogenesis Complement factor H (FH) and FH-related (FHR) proteins are associated with systemic and organ-specific pathologies including impaired defense against infections and incurable renal, eye and autoimmune diseases. While the biological function of FH is well-defined, the function of the other six highly homologous FHR proteins is mostly unknown, as is their role in the disease-specific pathogenic mechanisms. The EU-funded SciFiMed project will study the FH family proteins' contributions in health and disease aiming to obtain proof-of-principle for a multiplex detection system to simultaneously quantify and analyse the functional activity of all seven proteins in patient samples. This high-impact project will enable new product developments and provide new perspectives for patient treatments. Show the project objective Hide the project objective Objective This transdisciplinary project will combine fundamental immunological research with novel nanomaterial-based biosensor development translated into proof-of-principle diagnostics to revolutionize doctors’ ability to diagnose and treat severe diseases plaguing millions of Europeans. Impaired defence against infections, incurable renal, eye and autoimmune diseases represent a huge burden on human health and consequently cost our society not only personal suffering but also hundreds of billions of Euros p.a.. All of these diseases share an association with a dysregulation of the complement system, a major effector of the innate immune system. There still is a huge discrepancy between what we know and what we need to know about the complement system’s role in these diseases in order to prevent, diagnose and treat them appropriately, effectively, and efficiently . Complement factor H (FH) and FH-related (FHR) proteins are strongly associated with these systemic and organ-specific pathologies. In contrast to FH, the function of the remaining six highly homologous FHR proteins is mostly unknown and, hence, their role in the different disease-specific pathogenic mechanisms remain elusive. Our EU consortium (8 partners from 4 countries) will unravel the mysteries of the FH-protein family’s contributions to diseases. Then, via an ambitious and transdisciplinary fundamental science-to-technology transfer, a proof-of-principle for a multiplex detection system will be developed to simultaneously quantify and analyse the functional activity of all seven FH-protein family members in patient samples – on site, putting diagnostic technology directly into physicians’ hands. In the future, this high-impact project propels immunological research in Europe, enables new product development of bioanalytical companies, modernizes the EU-diagnostic market and provides new perspectives for patient treatment, which in turn will pave the way for novel approaches for drug development. Fields of science medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesbasic medicineimmunologyautoimmune diseasesmedical and health scienceshealth sciencespersonalized medicineengineering and technologymedical engineeringmedical laboratory technologydiagnostic technologies Keywords inflammation multiplex quantitative and functional biosensor complement diagnostics immunoassay liposome lysis assay point-of-care technology proof of principle complement factor H family Programme(s) H2020-EU.1.2. - EXCELLENT SCIENCE - Future and Emerging Technologies (FET) Main Programme H2020-EU.1.2.1. - FET Open Topic(s) FETOPEN-01-2018-2019-2020 - FET-Open Challenging Current Thinking Call for proposal H2020-FETOPEN-2018-2020 See other projects for this call Sub call H2020-FETOPEN-2018-2019-2020-01 Funding Scheme RIA - Research and Innovation action Coordinator PHILIPPS UNIVERSITAET MARBURG Net EU contribution € 778 750,00 Address BIEGENSTRASSE 10 35037 Marburg Germany See on map Region Hessen Gießen Marburg-Biedenkopf Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 778 750,00 Participants (8) Sort alphabetically Sort by Net EU contribution Expand all Collapse all UNIVERSITAET REGENSBURG Germany Net EU contribution € 657 426,25 Address UNIVERSITATSSTRASSE 31 93053 Regensburg See on map Region Bayern Oberpfalz Regensburg, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 657 426,25 UNIVERSIDAD COMPLUTENSE DE MADRID Spain Net EU contribution € 334 875,00 Address AVENIDA DE SENECA 2 28040 Madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 334 875,00 Stichting Sanquin Bloedvoorziening Netherlands Net EU contribution € 566 250,00 Address Plesmanlaan 125 1006 AN Amsterdam See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Research Organisations Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 566 250,00 EOTVOS LORAND TUDOMANYEGYETEM Hungary Net EU contribution € 350 000,00 Address EGYETEM TER 1-3 1053 Budapest See on map Region Közép-Magyarország Budapest Budapest Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 350 000,00 ACADEMISCH ZIEKENHUIS GRONINGEN Netherlands Net EU contribution € 328 750,00 Address HANZEPLEIN 1 9713 GZ Groningen See on map Region Noord-Nederland Groningen Overig Groningen Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 328 750,00 Hycult biotechnology bv Netherlands Net EU contribution € 190 000,00 Address Frontstraat 2A 5405 PB Uden See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Zuid-Nederland Noord-Brabant Noordoost-Noord-Brabant Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 322 000,00 MICROCOAT BIOTECHNOLOGIE GMBH Germany Net EU contribution € 353 750,00 Address AM NEULAND 3 82347 Bernried See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Bayern Oberbayern Weilheim-Schongau Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 353 750,00 KLINIKUM DER UNIVERSITAET REGENSBURG Participation ended Germany Net EU contribution € 0,00 Address FRANS JOSEF STRAUSS ALLEE 11 93053 Regensburg See on map Region Bayern Oberpfalz Regensburg, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data