Project description
Complement factor H-related proteins and their role in pathogenesis
Complement factor H (FH) and FH-related (FHR) proteins are associated with systemic and organ-specific pathologies including impaired defense against infections and incurable renal, eye and autoimmune diseases. While the biological function of FH is well-defined, the function of the other six highly homologous FHR proteins is mostly unknown, as is their role in the disease-specific pathogenic mechanisms. The EU-funded SciFiMed project will study the FH family proteins' contributions in health and disease aiming to obtain proof-of-principle for a multiplex detection system to simultaneously quantify and analyse the functional activity of all seven proteins in patient samples. This high-impact project will enable new product developments and provide new perspectives for patient treatments.
Objective
This transdisciplinary project will combine fundamental immunological research with novel nanomaterial-based biosensor development translated into proof-of-principle diagnostics to revolutionize doctors ability to diagnose and treat severe diseases plaguing millions of Europeans.
Impaired defence against infections, incurable renal, eye and autoimmune diseases represent a huge burden on human health and consequently cost our society not only personal suffering but also hundreds of billions of Euros p.a.. All of these diseases share an association with a dysregulation of the complement system, a major effector of the innate immune system. There still is a huge discrepancy between what we know and what we need to know about the complement systems role in these diseases in order to prevent, diagnose and treat them appropriately, effectively, and efficiently .
Complement factor H (FH) and FH-related (FHR) proteins are strongly associated with these systemic and organ-specific pathologies. In contrast to FH, the function of the remaining six highly homologous FHR proteins is mostly unknown and, hence, their role in the different disease-specific pathogenic mechanisms remain elusive.
Our EU consortium (8 partners from 4 countries) will unravel the mysteries of the FH-protein familys contributions to diseases. Then, via an ambitious and transdisciplinary fundamental science-to-technology transfer, a proof-of-principle for a multiplex detection system will be developed to simultaneously quantify and analyse the functional activity of all seven FH-protein family members in patient samples on site, putting diagnostic technology directly into physicians hands.
In the future, this high-impact project propels immunological research in Europe, enables new product development of bioanalytical companies, modernizes the EU-diagnostic market and provides new perspectives for patient treatment, which in turn will pave the way for novel approaches for drug development.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology electrical engineering, electronic engineering, information engineering electronic engineering sensors biosensors
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine pathology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.2. - EXCELLENT SCIENCE - Future and Emerging Technologies (FET)
MAIN PROGRAMME
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H2020-EU.1.2.1. - FET Open
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
RIA - Research and Innovation action
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-FETOPEN-2018-2020
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
35037 Marburg
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.