Screening of inFlammation to enable personalized Medicine

Project description

Complement factor H-related proteins and their role in pathogenesis

Complement factor H (FH) and FH-related (FHR) proteins are associated with systemic and organ-specific pathologies including impaired defense against infections and incurable renal, eye and autoimmune diseases. While the biological function of FH is well-defined, the function of the other six highly homologous FHR proteins is mostly unknown, as is their role in the disease-specific pathogenic mechanisms. The EU-funded SciFiMed project will study the FH family proteins' contributions in health and disease aiming to obtain proof-of-principle for a multiplex detection system to simultaneously quantify and analyse the functional activity of all seven proteins in patient samples. This high-impact project will enable new product developments and provide new perspectives for patient treatments.

Fields of science

• medical and health sciences › basic medicine › immunology › autoimmune diseases
• natural sciences › biological sciences › biochemistry › biomolecules › proteins
• engineering and technology › medical engineering › medical laboratory technology › diagnostic technologies

Programme(s)

• H2020-EU.1.2.1. - FET Open

Topic(s)

• FETOPEN-01-2018-2019-2020 - FET-Open Challenging Current Thinking

Call for proposal

H2020-FETOPEN-2018-2019-2020-01
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

PHILIPPS UNIVERSITAET MARBURG

Address

Biegenstrasse 10
35037 Marburg
Germany

Activity type

Higher or Secondary Education Establishments

EU contribution

€ 778 750

Participants (8)

UNIVERSITAET REGENSBURG

Germany

EU contribution

€ 657 426,25

Address

Universitatsstrasse 31
93053 Regensburg

Activity type

Higher or Secondary Education Establishments

UNIVERSIDAD COMPLUTENSE DE MADRID

Spain

EU contribution

€ 334 875

Address

Avenida De Seneca 2
28040 Madrid

Activity type

Higher or Secondary Education Establishments

Stichting Sanquin Bloedvoorziening

Netherlands

EU contribution

€ 566 250

Address

Plesmanlaan 125
1006 AN Amsterdam

Activity type

Research Organisations

EOTVOS LORAND TUDOMANYEGYETEM

Hungary

EU contribution

€ 350 000

Address

Egyetem Ter 1-3
1053 Budapest

Activity type

Higher or Secondary Education Establishments

ACADEMISCH ZIEKENHUIS GRONINGEN

Netherlands

EU contribution

€ 328 750

Address

Hanzeplein 1
9713 GZ Groningen

Activity type

Higher or Secondary Education Establishments

Hycult biotechnology bv

Netherlands

EU contribution

€ 190 000

Address

Frontstraat 2A
5405 PB Uden

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

MICROCOAT BIOTECHNOLOGIE GMBH

Germany

EU contribution

€ 353 750

Address

Am Neuland 3
82347 Bernried

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

KLINIKUM DER UNIVERSITAET REGENSBURG

Participation ended

Germany

EU contribution

€ 0

Address

Frans Josef Strauss Allee 11
93053 Regensburg

Activity type

Higher or Secondary Education Establishments