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Screening of inFlammation to enable personalized Medicine

Project description

Complement factor H-related proteins and their role in pathogenesis

Complement factor H (FH) and FH-related (FHR) proteins are associated with systemic and organ-specific pathologies including impaired defense against infections and incurable renal, eye and autoimmune diseases. While the biological function of FH is well-defined, the function of the other six highly homologous FHR proteins is mostly unknown, as is their role in the disease-specific pathogenic mechanisms. The EU-funded SciFiMed project will study the FH family proteins' contributions in health and disease aiming to obtain proof-of-principle for a multiplex detection system to simultaneously quantify and analyse the functional activity of all seven proteins in patient samples. This high-impact project will enable new product developments and provide new perspectives for patient treatments.

Field of science

  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins
  • /medical and health sciences/basic medicine/immunology

Call for proposal

H2020-FETOPEN-2018-2019-2020-01
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Funding Scheme

RIA - Research and Innovation action
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Coordinator

PHILIPPS UNIVERSITAET MARBURG
Address
Biegenstrasse 10
35037 Marburg
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 778 750

Participants (8)

UNIVERSITAET REGENSBURG
Germany
EU contribution
€ 657 426,25
Address
Universitatsstrasse 31
93053 Regensburg
Activity type
Higher or Secondary Education Establishments
UNIVERSIDAD COMPLUTENSE DE MADRID
Spain
EU contribution
€ 334 875
Address
Avenida De Seneca 2
28040 Madrid
Activity type
Higher or Secondary Education Establishments
Stichting Sanquin Bloedvoorziening
Netherlands
EU contribution
€ 566 250
Address
Plesmanlaan 125
1006 AN Amsterdam
Activity type
Research Organisations
EOTVOS LORAND TUDOMANYEGYETEM
Hungary
EU contribution
€ 350 000
Address
Egyetem Ter 1-3
1053 Budapest
Activity type
Higher or Secondary Education Establishments
ACADEMISCH ZIEKENHUIS GRONINGEN
Netherlands
EU contribution
€ 328 750
Address
Hanzeplein 1
9713 GZ Groningen
Activity type
Higher or Secondary Education Establishments
Hycult biotechnology bv
Netherlands
EU contribution
€ 190 000
Address
Frontstraat 2A
5405 PB Uden
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MICROCOAT BIOTECHNOLOGIE GMBH
Germany
EU contribution
€ 353 750
Address
Am Neuland 3
82347 Bernried
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
KLINIKUM DER UNIVERSITAET REGENSBURG

Participation ended

Germany
EU contribution
€ 0
Address
Frans Josef Strauss Allee 11
93053 Regensburg
Activity type
Higher or Secondary Education Establishments