Project description
Complement factor H-related proteins and their role in pathogenesis
Complement factor H (FH) and FH-related (FHR) proteins are associated with systemic and organ-specific pathologies including impaired defense against infections and incurable renal, eye and autoimmune diseases. While the biological function of FH is well-defined, the function of the other six highly homologous FHR proteins is mostly unknown, as is their role in the disease-specific pathogenic mechanisms. The EU-funded SciFiMed project will study the FH family proteins' contributions in health and disease aiming to obtain proof-of-principle for a multiplex detection system to simultaneously quantify and analyse the functional activity of all seven proteins in patient samples. This high-impact project will enable new product developments and provide new perspectives for patient treatments.
Fields of science
- medical and health sciencesbasic medicinepharmacology and pharmacydrug discovery
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteins
- medical and health sciencesbasic medicineimmunologyautoimmune diseases
- medical and health scienceshealth sciencespersonalized medicine
- engineering and technologymedical engineeringmedical laboratory technologydiagnostic technologies
Programme(s)
Funding Scheme
RIA - Research and Innovation action
Coordinator
35037 Marburg
Germany
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Participants (8)
93053 Regensburg
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28040 Madrid
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1006 AN Amsterdam
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1053 Budapest
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9713 GZ Groningen
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5405 PB Uden
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
82347 Bernried
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Participation ended
93053 Regensburg