Screening of inFlammation to enable personalized Medicine

Project Information

SciFiMed

Grant agreement ID: 899163

DOI 10.3030/899163

EC signature date 26 May 2020

Start date 1 January 2021

End date 30 June 2025

Funded under

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Total cost € 3 691 801,25

EU contribution € 3 559 801,25

Coordinated by

PHILIPPS UNIVERSITAET MARBURG
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (3)

LFA feasibility

Report on first 7pley LFA feasibilty study

Press release 1

Kick of Press release

Description dynamic range LFAs

Report dynamic ranges for all singleanalyte LFA

Websites, patent fillings, videos etc. (3)

Webpage, Logo and updates

Webpage proposed domain scifimedeu SciFiMed logo and continuous updates

SciFiMed Flyer
SciFiMed Video

SciFiMed introduction video

Publications

Peer reviewed articles (24)

A Family Affair: Addressing the Challenges of Factor H and the Related Proteins

Author(s): Felix Poppelaars, Elena Goicoechea de Jorge, Ilse Jongerius, Antje J. Baeumner, Mark-Steven Steiner, Mihály Józsi, Erik J. M. Toonen, Diana Pauly
Published in: Frontiers in Immunology, Issue 12, 2021, ISSN 1664-3224
Publisher: Lausanne: Frontiers Media S.A., 2010-
DOI: 10.3389/fimmu.2021.660194

Complement alternative pathway determines disease susceptibility and severity in antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis

Author(s): Laura Lucientes-Continente, Gema Fernández-Juárez, Bárbara Márquez-Tirado, Laura Jiménez-Villegas, Mercedes Acevedo, Teresa Cavero, Luís Sánchez Cámara, Juliana Draibe, Paula Anton-Pampols, Fernando Caravaca-Fontán, Manuel Praga, Javier Villacorta, Elena Goicoechea de Jorge
Published in: Kidney International, Issue 105, 2024, Page(s) 177-188, ISSN 0085-2538
Publisher: Blackwell Publishing Inc.
DOI: 10.1016/j.kint.2023.10.013

The human factor H protein family – an update

Author(s): Sándor, Noémi, Schneider, Andrea E., Matola, Alexandra T., Barbai, Veronika H., Bencze, Dániel, Hammad, Hani Hashim, Papp, Alexandra, Kövesdi, Dorottya, Uzonyi, Barbara, Józsi, Mihály
Published in: Frontiers In Immunology, Issue Volume 15 - 2024, 2024, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/fimmu.2024.1135490

Complement Factor H-Related Proteins FHR1 and FHR5 Interact With Extracellular Matrix Ligands, Reduce Factor H Regulatory Activity and Enhance Complement Activation.

Author(s): Alexandra Papp; Krisztián Papp; Barbara Uzonyi; Marcell Cserhalmi; Ádám I. Csincsi; Zsóka Szabó; Zsófia Bánlaki; David Ermert; Zoltán Prohászka; Anna Erdei; Viviana P. Ferreira; Anna M. Blom; Mihály Józsi
Published in: Frontiers in Immunology, Issue 13, 2022, ISSN 1664-3224
Publisher: Frontiers Media S.A.
DOI: 10.3389/fimmu.2022.845953

Editorial: Updates on the complement system in kidney diseases

Author(s): Bulla R., Józsi M
Published in: Frontiers in Immunology, Issue 14, 2023, ISSN 1664-3224
Publisher: Frontiers Media S.A.
DOI: 10.3389/fimmu.2023.1196487

Factor H-related 2 levels dictate FHR dimer composition

Author(s): Bert R. J. Veuskens, Mieke C. Brouwer, Gerard van Mierlo, Judy Geissler, Karin van Leeuwen, Maaike Derlagen, Nadia C. H. Keijzer, Mark Hoogenboezem, Taco W. Kuijpers, Richard B. Pouw
Published in: Scientific Reports, Issue 15, 2025, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-025-94064-4

Autoantibodies Against Factor B and Factor H Without Pathogenic Effects in a Patient with Immune Complex-Mediated Membranoproliferative Glomerulonephritis

Author(s): Alexandra T. Matola, Dorottya Csuka, Ágnes Szilágyi, Michael Rudnicki, Zoltán Prohászka, Mihály Józsi, Barbara Uzonyi
Published in: Biomedicines, Issue 13, 2025, Page(s) 648, ISSN 2227-9059
Publisher: MDPI AG
DOI: 10.3390/biomedicines13030648

Multiplexed electrochemical liposomes applied to the detection of nucleic acids for Influenza A, Influenza B and SARS-CoV-2

Author(s): Florian Gerstl, Michael Loessl, Veronika Borggraefe, Antje J. Baeumner
Published in: Analytical and Bioanalytical Chemistry, Issue 416, 2024, Page(s) 3487-3500, ISSN 1618-2642
Publisher: Springer Verlag
DOI: 10.1007/s00216-024-05145-8

Decreased complement 4 and interleukin-10 as biomarkers in aqueous humour for non-exudative age-related macular degeneration: a case control study

Author(s): Juliane Schikora, Aaron Dort, Hannah N. Wolf, Mihály Józsi, Richard B. Pouw, Thomas Bertelmann, Dirk Bahlmann, Christian van Oterendorp, Nicolas Feltgen, Hans Hoerauf, Diana Pauly, Jannis Klemming
Published in: Journal of Translational Medicine, Issue 23, 2025, ISSN 1479-5876
Publisher: BioMed Central
DOI: 10.1186/s12967-024-05909-x

The Factor H protein family: The switchers of the complement alternative pathway

Author(s): Laura Lucientes‐Continente; Bárbara Márquez‐Tirado; Elena Goicoechea de Jorge
Published in: Immunological Reviews, Issue 313(1), 2023, Page(s) 25-45, ISSN 0105-2896
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/imr.13166

Development and characterization of novel ELISAs for the specific quantification of the factor H-related proteins 2, 3, 4 and 5

Author(s): Mara van Rossum, Bert R.J. Veuskens, Mieke C. Brouwer, Gerard van Mierlo, Laura Lucientes-Continente, Elena Goicoechea de Jorge, Barbara Uzonyi, Alexandra T. Matola, Mihály Józsi, Günter Müller, Anita M. Meter-Arkema, Felix Poppelaars, Diana Pauly, Richard B. Pouw, Erik J.M. Toonen
Published in: Journal of Innate Immunity, 2025, Page(s) 1-24, ISSN 1662-811X
Publisher: Karger AG
DOI: 10.1159/000545139

The Contribution of Complement to the Pathogenesis of IgA Nephropathy: Are Complement-Targeted Therapies Moving from Rare Disorders to More Common Diseases?

Author(s): Felix Poppelaars; Bernardo Faria; Wilhelm Schwaeble; Mohamed R. Daha
Published in: Journal of Clinical Medicine, Issue Vol 10, Iss 4715, p 4715 (2021), 2021, ISSN 2077-0383
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.17863/cam.77005

Editorial: Function and Dysfunction of Complement Factor H

Author(s): Mihály Józsi, Pauli Nigel Barlow and Seppo Meri
Published in: Frontiers in Immunology, Issue 12, 2022, ISSN 1664-3224
Publisher: Frontiers S.A.
DOI: 10.3389/fimmu.2021.831044

Factor H-Related Protein 1 Drives Disease Susceptibility and Prognosis in C3 Glomerulopathy.

Author(s): Bárbara Márquez-Tirado; Josué Gutiérrez-Tenorio; Agustín Tortajada; Laura Lucientes Continente; Fernando Caravaca-Fontán; Talat H. Malik; Raquel Roldán Montero; Sandra Elías; Ana Saiz Gonzalez; Gema Fernández-Juarez; Pilar Sánchez-Corral; Matthew C. Pickering; Manuel Praga; Santiago Rodríguez de Córdoba; Elena Goicoechea de Jorge
Published in: Journal of the American Society of Nephrology, Issue Jun;33(6), 2022, Page(s) 1137-1153, ISSN 1046-6673
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1681/asn.2021101318

Evaluating the clinical utility of measuring levels of factor H and the related proteins

Author(s): Pratiti Banerjee; Bert R.J. Veuskens; Elena Goicoechea de Jorge; Mihály Józsi; Antje J. Baeumner; Mark-Steven Steiner; Richard B. Pouw; Erik J.M. Toonen; Diana Pauly; Felix Poppelaars
Published in: Molecular Immunology, Issue 151, 2022, ISSN 0161-5890
Publisher: Pergamon Press
DOI: 10.1016/j.molimm.2022.08.010

The Factor H protein family: The switchers of the complement alternative pathway

Author(s): Laura Lucientes‐Continente, Bárbara Márquez‐Tirado, Elena Goicoechea de Jorge
Published in: Immunological Reviews, Issue 313, 2023, Page(s) 25-45, ISSN 0105-2896
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/imr.13166

Prognostic significance of serum complement activation, neutrophil extracellular traps and extracellular DNA in newly diagnosed epithelial ovarian cancer

Author(s): Jason Ricciuti, Qian Liu, A.N.M. Nazmul H. Khan, Janine M. Joseph, Bert Veuskens, Thejaswini Giridharan, Sora Suzuki, Tiffany Emmons, Michael Yaffe, Taco W. Kuijpers, Ilse Jongerius, Mieke Brouwer, Richard B. Pouw, Kunle Odunsi, Peter Frederick, Katherine LaVigne Mager, Shashikant Lele, Nicole Gaulin, Christiane Hakim, Robert P. Edwards, Alexander B. Olawaiye, Paniti Sukamanovich, Sarah Taylor, Es
Published in: Gynecologic Oncology, Issue 193, 2025, Page(s) 49-57, ISSN 0090-8258
Publisher: Academic Press
DOI: 10.1016/j.ygyno.2024.12.006

Common haplotypes within the chromosome 1q31.3 region determine systemic concentrations of the entire complement factor H protein family

Author(s): Bert R.J. Veuskens, Mara Van Rossum, Emi Cattenstart, Mieke C. Brouwer, Gerard van Mierlo, Judy Geissler, Karin van Leeuwen, Jin Liu, Robert A. Anstadt, Burt T. Richards, Gregory S. Hageman, Taco W. Kuijpers, Erik J.M. Toonen, Richard B. Pouw
Published in: Journal of Innate Immunity, 2025, Page(s) 1-26, ISSN 1662-811X
Publisher: Karger AG
DOI: 10.1159/000545342

Complement Factor H Family Proteins Modulate Monocyte and Neutrophil Granulocyte Functions

Author(s): Éva Kárpáti, Mariann Kremlitzka, Noémi Sándor, Dávid Hajnal, Andrea E. Schneider and Mihály Józsi
Published in: Frontiers in Immunology, Issue 12:660852, 2021, ISSN 1664-3224
Publisher: Frontiers Media S.A.
DOI: 10.3389/fimmu.2021.660852

Pitfalls in complement analysis: A systematic literature review of assessing complement activation

Author(s): Ricardo J. M. G. E. Brandwijk, Marloes A. H. M. Michels, Mara van Rossum, Aline H. de Nooijer, Per H. Nilsson, Wieke C. C. de Bruin and Erik J. M. Toonen
Published in: Frontiers in Immunology, Issue 13, 2022, ISSN 1664-3224
Publisher: Frontiers S.A.
DOI: 10.3389/fimmu.2022.1007102

Complement Factor H-Related Proteins FHR1 and FHR5 Interact With Extracellular Matrix Ligands, Reduce Factor H Regulatory Activity and Enhance Complement Activation

Author(s): Alexandra Papp, Krisztián Papp, Barbara Uzonyi, Marcell Cserhalmi, Ádám I. Csincsi, Zsóka Szabó, Zsófia Bánlaki, David Ermert, Zoltán Prohászka, Anna Erdei, Viviana P. Ferreira, Anna M. Blom, Mihály Józsi
Published in: Frontiers in Immunology, Issue 13, 2023, Page(s) 845953, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2022.845953

Factor H–Related Protein 1 Drives Disease Susceptibility and Prognosis in C3 Glomerulopathy

Author(s): Bárbara Márquez-Tirado, Josué Gutiérrez-Tenorio, Agustín Tortajada, Laura Lucientes Continente, Fernando Caravaca-Fontán, Talat H. Malik, Raquel Roldán Montero, Sandra Elías, Ana Saiz Gonzalez, Gema Fernández-Juarez, Pilar Sánchez-Corral, Matthew C. Pickering, Manuel Praga, Santiago Rodríguez de Córdoba, Elena Goicoechea de Jorge
Published in: Journal of the American Society of Nephrology, Issue 33, 2024, Page(s) 1137-1153, ISSN 1046-6673
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1681/asn.2021101318

Complement Factor H-Related 3 Enhanced Inflammation and Complement Activation in Human RPE Cells

Author(s): Nicole Schäfer, Anas Rasras, Delia M. Ormenisan, Sabine Amslinger, Volker Enzmann, Herbert Jägle and Diana Pauly
Published in: Frontiers in Immunology, Issue 12:769242, 2021, ISSN 1664-3224
Publisher: Frontiers Media S.A
DOI: 10.3389/fimmu.2021.769242

Functional and structural characterization of mouse Factor H-related B protein unveils a novel dimerization domain shared by FHR-B and FH

Author(s): Adrián Martín-Ambrosio Doménech, Silvia González Sanz, Bárbara Márquez Tirado, Lucia Juana-López, Elena Goicoechea de Jorge, Santiago Rodríguez de Córdoba, Héctor Martín Merinero
Published in: Frontiers in Immunology, Issue 16, 2025, ISSN 1664-3224
Publisher: Frontiers Research Foundation
DOI: 10.3389/fimmu.2025.1522651

Non-peer reviewed articles (1)

Editorial: Current challenges in complement diagnostics

Author(s): Per H. Nilsson, Lillemor Skattum, Erik J. M. Toonen
Published in: Frontiers in Immunology, Issue 14, 2023, ISSN 1664-3224
Publisher: Frontiers Research Foundation
DOI: 10.3389/fimmu.2023.1334050