Project description
Novel 3D image-processing technology locates VT ablation targets
Patients at risk of ventricular tachycardia (VT) commonly undergo catheter ablation in the areas of myocardial scars responsible for arrhythmias. The initial phase of the intervention involves the intra-cardiac insertion of a mapping catheter which is invasive, often inaccurate and time-consuming. 3D cardiac imaging providing detailed structural information on ablation targets could overcome the shortcomings of this standard procedure. A recently developed novel 3D image-processing technology allows cardiologists to locate VT ablation targets and guide ablation procedures in a non-invasive, highly precise and rapid manner using widely available cardiac CT images. The EU-funded MAP-IN-HEART project will investigate the technical and economical feasibility of the innovative approach by assessing its efficacy and safety in a limited clinical study.
Objective
Patients at risk of ventricular tachycardia (VT), the primary cause of sudden cardiac death, commonly undergo catheter ablation to cauterize the areas within myocardial scars responsible for arrythmias. However, the initial phase of the intervention devoted to identifying the ablation targets currently involves the intra-cardiac insertion of a mapping catheter characterized for being invasive, often inaccurate, and time-consuming. Pre-operative implementation of 3D cardiac imaging approaches to provide detailed structural information on ablation targets could overcome the shortcomings of standard catheter-based mapping. Still, state-of-the-art techniques have not lived up to their potential so far. During his ERC Starting Grant ECSTATIC (2017-2022), Prof. Hubert Cochet at University of Bordeaux developed a novel 3D image-processing technology (MAP-IN-HEART) which would allow cardiologists to locate VT ablation targets and guide ablation procedures in a non-invasive, highly precise and rapid manner using widely available cardiac CT images, without the need for a mapping catheter. In this ERC PoC project, we will investigate the technical feasibility of the innovative MAP-IN-HEART approach by assessing its efficiency and safety in a limited clinical study, and performing a cost-efficiency analysis. Moreover, we will ensure Freedom-To-Operate and explore all the potential paths for commercialization to finally develop a viable business strategy based on the technological aspects, the market needs and trends. Lastly, during this project we will gain technical and commercial proof-of-concept, providing the necessary information for potential commercialisation routes.
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Funding Scheme
ERC-POC - Proof of Concept GrantHost institution
33000 Bordeaux
France